Cargando…

Genetic Determinants of Telomere Length in African American Youth

Telomere length (TL) is associated with numerous disease states and is affected by genetic and environmental factors. However, TL has been mostly studied in adult populations of European or Asian ancestry. These studies have identified 34 TL-associated genetic variants recently used as genetic proxi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeiger, Andrew M., White, Marquitta J., Eng, Celeste, Oh, Sam S., Witonsky, Jonathan, Goddard, Pagé C., Contreras, Maria G., Elhawary, Jennifer R., Hu, Donglei, Mak, Angel C. Y., Lee, Eunice Y., Keys, Kevin L., Samedy, Lesly-Anne, Risse-Adams, Oona, Magaña, Joaquín, Huntsman, Scott, Salazar, Sandra, Davis, Adam, Meade, Kelley, Brigino-Buenaventura, Emerita, LeNoir, Michael A., Farber, Harold J., Bibbins-Domingo, Kirsten, Borrell, Luisa N., Burchard, Esteban G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125592/
https://www.ncbi.nlm.nih.gov/pubmed/30185882
http://dx.doi.org/10.1038/s41598-018-31238-3
_version_ 1783353185426997248
author Zeiger, Andrew M.
White, Marquitta J.
Eng, Celeste
Oh, Sam S.
Witonsky, Jonathan
Goddard, Pagé C.
Contreras, Maria G.
Elhawary, Jennifer R.
Hu, Donglei
Mak, Angel C. Y.
Lee, Eunice Y.
Keys, Kevin L.
Samedy, Lesly-Anne
Risse-Adams, Oona
Magaña, Joaquín
Huntsman, Scott
Salazar, Sandra
Davis, Adam
Meade, Kelley
Brigino-Buenaventura, Emerita
LeNoir, Michael A.
Farber, Harold J.
Bibbins-Domingo, Kirsten
Borrell, Luisa N.
Burchard, Esteban G.
author_facet Zeiger, Andrew M.
White, Marquitta J.
Eng, Celeste
Oh, Sam S.
Witonsky, Jonathan
Goddard, Pagé C.
Contreras, Maria G.
Elhawary, Jennifer R.
Hu, Donglei
Mak, Angel C. Y.
Lee, Eunice Y.
Keys, Kevin L.
Samedy, Lesly-Anne
Risse-Adams, Oona
Magaña, Joaquín
Huntsman, Scott
Salazar, Sandra
Davis, Adam
Meade, Kelley
Brigino-Buenaventura, Emerita
LeNoir, Michael A.
Farber, Harold J.
Bibbins-Domingo, Kirsten
Borrell, Luisa N.
Burchard, Esteban G.
author_sort Zeiger, Andrew M.
collection PubMed
description Telomere length (TL) is associated with numerous disease states and is affected by genetic and environmental factors. However, TL has been mostly studied in adult populations of European or Asian ancestry. These studies have identified 34 TL-associated genetic variants recently used as genetic proxies for TL. The generalizability of these associations to pediatric populations and racially diverse populations, specifically of African ancestry, remains unclear. Furthermore, six novel variants associated with TL in a population of European children have been identified but not validated. We measured TL from whole blood samples of 492 healthy African American youth (children and adolescents between 8 and 20 years old) and performed the first genome-wide association study of TL in this population. We were unable to replicate neither the 34 reported genetic associations found in adults nor the six genetic associations found in European children. However, we discovered a novel genome-wide significant association between TL and rs1483898 on chromosome 14. Our results underscore the importance of examining genetic associations with TL in diverse pediatric populations such as African Americans.
format Online
Article
Text
id pubmed-6125592
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61255922018-09-10 Genetic Determinants of Telomere Length in African American Youth Zeiger, Andrew M. White, Marquitta J. Eng, Celeste Oh, Sam S. Witonsky, Jonathan Goddard, Pagé C. Contreras, Maria G. Elhawary, Jennifer R. Hu, Donglei Mak, Angel C. Y. Lee, Eunice Y. Keys, Kevin L. Samedy, Lesly-Anne Risse-Adams, Oona Magaña, Joaquín Huntsman, Scott Salazar, Sandra Davis, Adam Meade, Kelley Brigino-Buenaventura, Emerita LeNoir, Michael A. Farber, Harold J. Bibbins-Domingo, Kirsten Borrell, Luisa N. Burchard, Esteban G. Sci Rep Article Telomere length (TL) is associated with numerous disease states and is affected by genetic and environmental factors. However, TL has been mostly studied in adult populations of European or Asian ancestry. These studies have identified 34 TL-associated genetic variants recently used as genetic proxies for TL. The generalizability of these associations to pediatric populations and racially diverse populations, specifically of African ancestry, remains unclear. Furthermore, six novel variants associated with TL in a population of European children have been identified but not validated. We measured TL from whole blood samples of 492 healthy African American youth (children and adolescents between 8 and 20 years old) and performed the first genome-wide association study of TL in this population. We were unable to replicate neither the 34 reported genetic associations found in adults nor the six genetic associations found in European children. However, we discovered a novel genome-wide significant association between TL and rs1483898 on chromosome 14. Our results underscore the importance of examining genetic associations with TL in diverse pediatric populations such as African Americans. Nature Publishing Group UK 2018-09-05 /pmc/articles/PMC6125592/ /pubmed/30185882 http://dx.doi.org/10.1038/s41598-018-31238-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zeiger, Andrew M.
White, Marquitta J.
Eng, Celeste
Oh, Sam S.
Witonsky, Jonathan
Goddard, Pagé C.
Contreras, Maria G.
Elhawary, Jennifer R.
Hu, Donglei
Mak, Angel C. Y.
Lee, Eunice Y.
Keys, Kevin L.
Samedy, Lesly-Anne
Risse-Adams, Oona
Magaña, Joaquín
Huntsman, Scott
Salazar, Sandra
Davis, Adam
Meade, Kelley
Brigino-Buenaventura, Emerita
LeNoir, Michael A.
Farber, Harold J.
Bibbins-Domingo, Kirsten
Borrell, Luisa N.
Burchard, Esteban G.
Genetic Determinants of Telomere Length in African American Youth
title Genetic Determinants of Telomere Length in African American Youth
title_full Genetic Determinants of Telomere Length in African American Youth
title_fullStr Genetic Determinants of Telomere Length in African American Youth
title_full_unstemmed Genetic Determinants of Telomere Length in African American Youth
title_short Genetic Determinants of Telomere Length in African American Youth
title_sort genetic determinants of telomere length in african american youth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125592/
https://www.ncbi.nlm.nih.gov/pubmed/30185882
http://dx.doi.org/10.1038/s41598-018-31238-3
work_keys_str_mv AT zeigerandrewm geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT whitemarquittaj geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT engceleste geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT ohsams geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT witonskyjonathan geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT goddardpagec geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT contrerasmariag geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT elhawaryjenniferr geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT hudonglei geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT makangelcy geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT leeeunicey geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT keyskevinl geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT samedyleslyanne geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT risseadamsoona geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT maganajoaquin geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT huntsmanscott geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT salazarsandra geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT davisadam geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT meadekelley geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT briginobuenaventuraemerita geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT lenoirmichaela geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT farberharoldj geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT bibbinsdomingokirsten geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT borrellluisan geneticdeterminantsoftelomerelengthinafricanamericanyouth
AT burchardestebang geneticdeterminantsoftelomerelengthinafricanamericanyouth