EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

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The transcriptional regulator EVI1 has an essential role in early hematopoiesis and development. However, aberrantly high expression of EVI1 has potent oncogenic properties and confers poor prognosis and chemo-resistance in leukemia and solid tumors. To investigate to what extent EVI1 function might...

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Detalles Bibliográficos
Autores principales: Paredes, Roberto, Schneider, Marion, Stevens, Adam, White, Daniel J, Williamson, Andrew J K, Muter, Joanne, Pearson, Stella, Kelly, James R, Connors, Kathleen, Wiseman, Daniel H, Chadwick, John A, Löffler, Harald, Teng, Hsiang Ying, Lovell, Simon, Unwin, Richard, van de Vrugt, Henri J, Smith, Helen, Kustikova, Olga, Schambach, Axel, Somervaille, Tim C P, Pierce, Andrew, Whetton, Anthony D, Meyer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125627/
https://www.ncbi.nlm.nih.gov/pubmed/29939287
http://dx.doi.org/10.1093/nar/gky536

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