Toward predictive R-loop computational biology: genome-scale prediction of R-loops reveals their association with complex promoter structures, G-quadruplexes and transcriptionally active enhancers

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R-loops are three-stranded RNA:DNA hybrid structures essential for many normal and pathobiological processes. Previously, we generated a quantitative R-loop forming sequence (RLFS) model, quantitative model of R-loop-forming sequences (QmRLFS) and predicted ∼660 000 RLFSs; most of them located in ge...

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Detalles Bibliográficos
Autores principales: Kuznetsov, Vladimir A, Bondarenko, Vladyslav, Wongsurawat, Thidathip, Yenamandra, Surya P, Jenjaroenpun, Piroon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125637/
https://www.ncbi.nlm.nih.gov/pubmed/29945198
http://dx.doi.org/10.1093/nar/gky554
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