Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage

Linker histone H1 has a key role in maintaining higher order chromatin structure and genome stability, but how H1 functions in these processes is elusive. Here, we report that acetylation of lysine 85 (K85) within the H1 globular domain is a critical post-translational modification that regulates ch...

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Detalles Bibliográficos
Autores principales: Li, Yinglu, Li, Zhiming, Dong, Liping, Tang, Ming, Zhang, Ping, Zhang, Chaohua, Cao, Ziyang, Zhu, Qian, Chen, Yongcan, Wang, Hui, Wang, Tianzhuo, Lv, Danyu, Wang, Lina, Zhao, Ying, Yang, Yang, Wang, Haiying, Zhang, Hongquan, Roeder, Robert G, Zhu, Wei-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125638/
https://www.ncbi.nlm.nih.gov/pubmed/29982688
http://dx.doi.org/10.1093/nar/gky568

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