Cargando…
Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein?
BACKGROUND: Baclofen has shown promise in the treatment of alcohol dependence. However, its precise (neuro-) psychological working mechanism is still under debate. AIMS: This study aimed to get a better understanding of baclofen’s working mechanism by examining the effect of baclofen on cognitive bi...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125818/ https://www.ncbi.nlm.nih.gov/pubmed/29897022 http://dx.doi.org/10.1177/0269881118780010 |
_version_ | 1783353224593408000 |
---|---|
author | Beraha, Esther M Salemink, Elske Krediet, Erwin Wiers, Reinout W |
author_facet | Beraha, Esther M Salemink, Elske Krediet, Erwin Wiers, Reinout W |
author_sort | Beraha, Esther M |
collection | PubMed |
description | BACKGROUND: Baclofen has shown promise in the treatment of alcohol dependence. However, its precise (neuro-) psychological working mechanism is still under debate. AIMS: This study aimed to get a better understanding of baclofen’s working mechanism by examining the effect of baclofen on cognitive biases. It was hypothesized that baclofen, compared to placebo, would lead to weaker cognitive biases. Furthermore, given a suggested anxiolytic effect of baclofen, we expected that anxiety would moderate this effect. METHODS: From a larger randomized clinical trial (RCT) with 151 participants, a subset of 143 detoxified alcohol-dependent patients, either taking baclofen or placebo, was examined. Attentional bias for alcohol (500 and 1500 ms), alcohol approach tendencies, implicit alcohol-relaxation associations and trait anxiety were assessed before the administration of baclofen or placebo. Four weeks later, 94 patients were still abstinent (53 in the baclofen and 41 in the placebo condition) and cognitive biases were assessed again. RESULTS: At baseline, patients showed a vigilance-avoidance pattern for the attentional bias (at 500 and 1500 ms, respectively) and alcohol-negative associations. After 4 weeks, an indication for an attentional bias away from alcohol at 500 ms was found only in the baclofen group; however, cognitive biases did not differ significantly between treatment groups. No moderating role of anxiety on cognitive biases was found. CONCLUSIONS: Baclofen did not lead to a differential change in cognitive biases compared with placebo, and trait anxiety levels did not moderate this. A better understanding of the working mechanism of baclofen and predictors of treatment success would allow prescribing of baclofen in a more targeted manner. |
format | Online Article Text |
id | pubmed-6125818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-61258182018-09-19 Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? Beraha, Esther M Salemink, Elske Krediet, Erwin Wiers, Reinout W J Psychopharmacol Original Papers BACKGROUND: Baclofen has shown promise in the treatment of alcohol dependence. However, its precise (neuro-) psychological working mechanism is still under debate. AIMS: This study aimed to get a better understanding of baclofen’s working mechanism by examining the effect of baclofen on cognitive biases. It was hypothesized that baclofen, compared to placebo, would lead to weaker cognitive biases. Furthermore, given a suggested anxiolytic effect of baclofen, we expected that anxiety would moderate this effect. METHODS: From a larger randomized clinical trial (RCT) with 151 participants, a subset of 143 detoxified alcohol-dependent patients, either taking baclofen or placebo, was examined. Attentional bias for alcohol (500 and 1500 ms), alcohol approach tendencies, implicit alcohol-relaxation associations and trait anxiety were assessed before the administration of baclofen or placebo. Four weeks later, 94 patients were still abstinent (53 in the baclofen and 41 in the placebo condition) and cognitive biases were assessed again. RESULTS: At baseline, patients showed a vigilance-avoidance pattern for the attentional bias (at 500 and 1500 ms, respectively) and alcohol-negative associations. After 4 weeks, an indication for an attentional bias away from alcohol at 500 ms was found only in the baclofen group; however, cognitive biases did not differ significantly between treatment groups. No moderating role of anxiety on cognitive biases was found. CONCLUSIONS: Baclofen did not lead to a differential change in cognitive biases compared with placebo, and trait anxiety levels did not moderate this. A better understanding of the working mechanism of baclofen and predictors of treatment success would allow prescribing of baclofen in a more targeted manner. SAGE Publications 2018-06-13 2018-08 /pmc/articles/PMC6125818/ /pubmed/29897022 http://dx.doi.org/10.1177/0269881118780010 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Papers Beraha, Esther M Salemink, Elske Krediet, Erwin Wiers, Reinout W Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? |
title | Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? |
title_full | Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? |
title_fullStr | Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? |
title_full_unstemmed | Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? |
title_short | Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? |
title_sort | can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125818/ https://www.ncbi.nlm.nih.gov/pubmed/29897022 http://dx.doi.org/10.1177/0269881118780010 |
work_keys_str_mv | AT berahaestherm canbaclofenchangealcoholrelatedcognitivebiasesandwhatistheroleofanxietyherein AT saleminkelske canbaclofenchangealcoholrelatedcognitivebiasesandwhatistheroleofanxietyherein AT kredieterwin canbaclofenchangealcoholrelatedcognitivebiasesandwhatistheroleofanxietyherein AT wiersreinoutw canbaclofenchangealcoholrelatedcognitivebiasesandwhatistheroleofanxietyherein |