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A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse
OBJECTIVE: The GH-2000 biomarker test has been introduced by the World Anti-Doping Agency as a method of detecting growth hormone misuse in professional sport. The test involves the measurement insulin-like growth factor-I and the amino-terminal pro-peptide of type III collagen (P-III-NP) which incr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125940/ https://www.ncbi.nlm.nih.gov/pubmed/30185229 http://dx.doi.org/10.1186/s13104-018-3741-7 |
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author | Böhning, Dankmar Böhning, Walailuck Guha, Nishan Cowan, David A. Bartlett, Christiaan Sönksen, Peter H. Holt, Richard I. G. |
author_facet | Böhning, Dankmar Böhning, Walailuck Guha, Nishan Cowan, David A. Bartlett, Christiaan Sönksen, Peter H. Holt, Richard I. G. |
author_sort | Böhning, Dankmar |
collection | PubMed |
description | OBJECTIVE: The GH-2000 biomarker test has been introduced by the World Anti-Doping Agency as a method of detecting growth hormone misuse in professional sport. The test involves the measurement insulin-like growth factor-I and the amino-terminal pro-peptide of type III collagen (P-III-NP) which increase in a dose-dependent manner in response to GH. These measurements are combined in sex specific formulae that include an age adjustment. The original age adjustment overcorrects the effect of age in male athletes and could potentially place older men at a disadvantage. The purpose of this note is to investigate the performance of a previously suggested correction term in two new and larger data sets. RESULTS: The GH-2000 score was calculated for 7307 samples obtained from 15 accredited WADA laboratories in 2017 and 3916 samples measured at Drug Control Centre, King’s College London, UK between 2013 and 2017. The GH-2000 scores were investigated for positive age effects using standard regression modelling. As previously, all analyses confirmed a positive age effect. Applying the earlier suggested correction term of 0.032 × age showed a significant over-correction leading to a negative association of the GH-2000 score with age. We now suggest a smaller age correction of 0.020 × age, which corresponds to the smallest effect found in the earlier studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3741-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6125940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61259402018-09-10 A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse Böhning, Dankmar Böhning, Walailuck Guha, Nishan Cowan, David A. Bartlett, Christiaan Sönksen, Peter H. Holt, Richard I. G. BMC Res Notes Research Note OBJECTIVE: The GH-2000 biomarker test has been introduced by the World Anti-Doping Agency as a method of detecting growth hormone misuse in professional sport. The test involves the measurement insulin-like growth factor-I and the amino-terminal pro-peptide of type III collagen (P-III-NP) which increase in a dose-dependent manner in response to GH. These measurements are combined in sex specific formulae that include an age adjustment. The original age adjustment overcorrects the effect of age in male athletes and could potentially place older men at a disadvantage. The purpose of this note is to investigate the performance of a previously suggested correction term in two new and larger data sets. RESULTS: The GH-2000 score was calculated for 7307 samples obtained from 15 accredited WADA laboratories in 2017 and 3916 samples measured at Drug Control Centre, King’s College London, UK between 2013 and 2017. The GH-2000 scores were investigated for positive age effects using standard regression modelling. As previously, all analyses confirmed a positive age effect. Applying the earlier suggested correction term of 0.032 × age showed a significant over-correction leading to a negative association of the GH-2000 score with age. We now suggest a smaller age correction of 0.020 × age, which corresponds to the smallest effect found in the earlier studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3741-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-09-05 /pmc/articles/PMC6125940/ /pubmed/30185229 http://dx.doi.org/10.1186/s13104-018-3741-7 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Böhning, Dankmar Böhning, Walailuck Guha, Nishan Cowan, David A. Bartlett, Christiaan Sönksen, Peter H. Holt, Richard I. G. A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse |
title | A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse |
title_full | A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse |
title_fullStr | A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse |
title_full_unstemmed | A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse |
title_short | A correction to the age-adjustment of the GH-2000 score used in the detection of growth hormone misuse |
title_sort | correction to the age-adjustment of the gh-2000 score used in the detection of growth hormone misuse |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125940/ https://www.ncbi.nlm.nih.gov/pubmed/30185229 http://dx.doi.org/10.1186/s13104-018-3741-7 |
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