Overexpression of the Drosophila ATR homologous checkpoint kinase Mei-41 induces a G2/M checkpoint in Drosophila imaginal tissue

BACKGROUND: DNA damage generally results in the activation of ATM/ATR kinases and the downstream checkpoint kinases Chk1/Chk2. In Drosophila melanogaster, the ATR homologue meiotic 41 (mei-41) is pivotal to DNA damage repair and cell cycle checkpoint signalling. Although various mei-41 mutant allele...

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Detalles Bibliográficos
Autores principales: Bayer, Fabienne E., Zimmermann, Mirjam, Preiss, Anette, Nagel, Anja C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125995/
https://www.ncbi.nlm.nih.gov/pubmed/30202398
http://dx.doi.org/10.1186/s41065-018-0066-4

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