Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs

The melanoma antigen gene (MAGE) proteins are a group of highly conserved family members that contain a common MAGE homology domain. Type I MAGEs are relevant cancer-testis antigens (CTAs), and originally considered as attractive targets for cancer immunotherapy due to their typically high expressio...

Descripción completa

Detalles Bibliográficos
Autores principales: Lian, Yishui, Meng, Lingjiao, Ding, Pingan, Sang, Meixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126015/
https://www.ncbi.nlm.nih.gov/pubmed/30185218
http://dx.doi.org/10.1186/s13148-018-0550-8
_version_ 1783353255807418368
author Lian, Yishui
Meng, Lingjiao
Ding, Pingan
Sang, Meixiang
author_facet Lian, Yishui
Meng, Lingjiao
Ding, Pingan
Sang, Meixiang
author_sort Lian, Yishui
collection PubMed
description The melanoma antigen gene (MAGE) proteins are a group of highly conserved family members that contain a common MAGE homology domain. Type I MAGEs are relevant cancer-testis antigens (CTAs), and originally considered as attractive targets for cancer immunotherapy due to their typically high expression in tumor tissues but restricted expression in normal adult tissues. Here, we reviewed the recent discoveries and ideas that illustrate the biological functions of MAGE family in cancer progression. Furthermore, we also highlighted the current understanding of the epigenetic mechanism of MAGE family expression in human cancers.
format Online
Article
Text
id pubmed-6126015
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-61260152018-09-10 Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs Lian, Yishui Meng, Lingjiao Ding, Pingan Sang, Meixiang Clin Epigenetics Review The melanoma antigen gene (MAGE) proteins are a group of highly conserved family members that contain a common MAGE homology domain. Type I MAGEs are relevant cancer-testis antigens (CTAs), and originally considered as attractive targets for cancer immunotherapy due to their typically high expression in tumor tissues but restricted expression in normal adult tissues. Here, we reviewed the recent discoveries and ideas that illustrate the biological functions of MAGE family in cancer progression. Furthermore, we also highlighted the current understanding of the epigenetic mechanism of MAGE family expression in human cancers. BioMed Central 2018-09-05 /pmc/articles/PMC6126015/ /pubmed/30185218 http://dx.doi.org/10.1186/s13148-018-0550-8 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Lian, Yishui
Meng, Lingjiao
Ding, Pingan
Sang, Meixiang
Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs
title Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs
title_full Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs
title_fullStr Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs
title_full_unstemmed Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs
title_short Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs
title_sort epigenetic regulation of mage family in human cancer progression-dna methylation, histone modification, and non-coding rnas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126015/
https://www.ncbi.nlm.nih.gov/pubmed/30185218
http://dx.doi.org/10.1186/s13148-018-0550-8
work_keys_str_mv AT lianyishui epigeneticregulationofmagefamilyinhumancancerprogressiondnamethylationhistonemodificationandnoncodingrnas
AT menglingjiao epigeneticregulationofmagefamilyinhumancancerprogressiondnamethylationhistonemodificationandnoncodingrnas
AT dingpingan epigeneticregulationofmagefamilyinhumancancerprogressiondnamethylationhistonemodificationandnoncodingrnas
AT sangmeixiang epigeneticregulationofmagefamilyinhumancancerprogressiondnamethylationhistonemodificationandnoncodingrnas

Ejemplares similares