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Effect of duration of diabetes on bone mineral density: a population study on East Asian males
BACKGROUND: The aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126021/ https://www.ncbi.nlm.nih.gov/pubmed/30185190 http://dx.doi.org/10.1186/s12902-018-0290-y |
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author | Jang, Miso Kim, Hyunkyung Lea, Shorry Oh, Sohee Kim, Jong Seung Oh, Bumjo |
author_facet | Jang, Miso Kim, Hyunkyung Lea, Shorry Oh, Sohee Kim, Jong Seung Oh, Bumjo |
author_sort | Jang, Miso |
collection | PubMed |
description | BACKGROUND: The aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011. METHODS: In total, 37,753 individuals participated in health examination surveys between 2008 and 2011. A total of 3383 males aged ≥50 years were eligible. They underwent BMD measurement through dual-energy X-ray absorptiometry (DXA). The fasting plasma glucose and insulin levels of participants were also measured. RESULTS: Men with prediabetes and diabetes had significantly higher mean BMD at all measured sites than control men did, irrespective of DM status. This was confirmed by multivariable linear regression analyses. DM duration was an important factor affecting BMD. Patients with DM for > 5 years had lower mean BMD in the total hip and femoral neck than those with DM for ≤5 years. Per multivariable linear regression analyses, patients with DM for > 5 years had significantly lower mean BMD at the femoral neck than those with DM ≤5 years. CONCLUSIONS: DM duration was significantly associated with reduced femoral neck BMD. |
format | Online Article Text |
id | pubmed-6126021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61260212018-09-10 Effect of duration of diabetes on bone mineral density: a population study on East Asian males Jang, Miso Kim, Hyunkyung Lea, Shorry Oh, Sohee Kim, Jong Seung Oh, Bumjo BMC Endocr Disord Research Article BACKGROUND: The aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011. METHODS: In total, 37,753 individuals participated in health examination surveys between 2008 and 2011. A total of 3383 males aged ≥50 years were eligible. They underwent BMD measurement through dual-energy X-ray absorptiometry (DXA). The fasting plasma glucose and insulin levels of participants were also measured. RESULTS: Men with prediabetes and diabetes had significantly higher mean BMD at all measured sites than control men did, irrespective of DM status. This was confirmed by multivariable linear regression analyses. DM duration was an important factor affecting BMD. Patients with DM for > 5 years had lower mean BMD in the total hip and femoral neck than those with DM for ≤5 years. Per multivariable linear regression analyses, patients with DM for > 5 years had significantly lower mean BMD at the femoral neck than those with DM ≤5 years. CONCLUSIONS: DM duration was significantly associated with reduced femoral neck BMD. BioMed Central 2018-09-05 /pmc/articles/PMC6126021/ /pubmed/30185190 http://dx.doi.org/10.1186/s12902-018-0290-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Jang, Miso Kim, Hyunkyung Lea, Shorry Oh, Sohee Kim, Jong Seung Oh, Bumjo Effect of duration of diabetes on bone mineral density: a population study on East Asian males |
title | Effect of duration of diabetes on bone mineral density: a population study on East Asian males |
title_full | Effect of duration of diabetes on bone mineral density: a population study on East Asian males |
title_fullStr | Effect of duration of diabetes on bone mineral density: a population study on East Asian males |
title_full_unstemmed | Effect of duration of diabetes on bone mineral density: a population study on East Asian males |
title_short | Effect of duration of diabetes on bone mineral density: a population study on East Asian males |
title_sort | effect of duration of diabetes on bone mineral density: a population study on east asian males |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126021/ https://www.ncbi.nlm.nih.gov/pubmed/30185190 http://dx.doi.org/10.1186/s12902-018-0290-y |
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