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Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes

BACKGROUND: To investigate changes in corneal elevation, pachymetry, and keratometry in discriminating between normal and blepharospasm eyes, as measured by the Pentacam rotating Scheimpflug camera. METHODS: This was a prospective, cross-sectional study. A total of 47 consecutive patients with a ran...

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Autores principales: Zhang, Huina, Zhou, Hongjie, Zhu, Tiepei, Ye, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126042/
https://www.ncbi.nlm.nih.gov/pubmed/30185154
http://dx.doi.org/10.1186/s12886-018-0897-9
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author Zhang, Huina
Zhou, Hongjie
Zhu, Tiepei
Ye, Juan
author_facet Zhang, Huina
Zhou, Hongjie
Zhu, Tiepei
Ye, Juan
author_sort Zhang, Huina
collection PubMed
description BACKGROUND: To investigate changes in corneal elevation, pachymetry, and keratometry in discriminating between normal and blepharospasm eyes, as measured by the Pentacam rotating Scheimpflug camera. METHODS: This was a prospective, cross-sectional study. A total of 47 consecutive patients with a range of blepharospasm severity and 40 age- and sex- matched healthy subjects were included, one eye of each subject was randomly chosen for data analysis. Blepharospasm severity was evaluated using the Jankovic scale and categorized as mild, moderate, or severe. Corneal parameters were measured by the Pentacam rotating Scheimpflug camera to derive corneal tomography information. Various parameters regarding keratometry, elevation at the anterior and posterior corneal surface, pachymetric data, final D value, and topometric indices from the Pentacam software were recorded, and the relationship between the blink rate and corneal parameters was analyzed. Intraclass correlation coefficients (ICCs) were assessed to evaluate the repeatability of intraobserver. RESULTS: Increased topographic asymmetry was observed in moderate and severe blepharospasm. Front K1and front Km were significantly higher in cases of mild (P < 0.05), moderate (P < 0.0001), and severe (P < 0.0001) blepharospasm as compared with controls. Front K2, back K1, back K2, and back Km were significantly higher in cases of moderate (P < 0.01) and severe (P < 0.001) blepharospasm as compared with controls. For corneal topometric indices, both ISV and IVA were significantly increased in severe blepharospasm (P < 0.05). Radii minimum were significantly increased in cases of moderate and severe blepharospasm (P < 0.05).There were no differences in corneal elevation and corneal pharcymetric parameters among the four groups, except for front BFS, which was significantly different in blepharospasm groups (P < 0.05). Final D values were significantly higher in the severe blepharospasm (P < 0.01) group than that among controls. There were significant correlations between the blink rate and most corneal tomographic parameters. All parameters showed high reproducibility (ICC: 0.921–0.996) for normal and blepharospasm subjects. CONCLUSIONS: Blepharospasm may lead to a redistribution of the pressure applied by the lids over the cornea and, consequently, may result in corneal shape changes, which can be documented through corneal topography.
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spelling pubmed-61260422018-09-10 Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes Zhang, Huina Zhou, Hongjie Zhu, Tiepei Ye, Juan BMC Ophthalmol Research Article BACKGROUND: To investigate changes in corneal elevation, pachymetry, and keratometry in discriminating between normal and blepharospasm eyes, as measured by the Pentacam rotating Scheimpflug camera. METHODS: This was a prospective, cross-sectional study. A total of 47 consecutive patients with a range of blepharospasm severity and 40 age- and sex- matched healthy subjects were included, one eye of each subject was randomly chosen for data analysis. Blepharospasm severity was evaluated using the Jankovic scale and categorized as mild, moderate, or severe. Corneal parameters were measured by the Pentacam rotating Scheimpflug camera to derive corneal tomography information. Various parameters regarding keratometry, elevation at the anterior and posterior corneal surface, pachymetric data, final D value, and topometric indices from the Pentacam software were recorded, and the relationship between the blink rate and corneal parameters was analyzed. Intraclass correlation coefficients (ICCs) were assessed to evaluate the repeatability of intraobserver. RESULTS: Increased topographic asymmetry was observed in moderate and severe blepharospasm. Front K1and front Km were significantly higher in cases of mild (P < 0.05), moderate (P < 0.0001), and severe (P < 0.0001) blepharospasm as compared with controls. Front K2, back K1, back K2, and back Km were significantly higher in cases of moderate (P < 0.01) and severe (P < 0.001) blepharospasm as compared with controls. For corneal topometric indices, both ISV and IVA were significantly increased in severe blepharospasm (P < 0.05). Radii minimum were significantly increased in cases of moderate and severe blepharospasm (P < 0.05).There were no differences in corneal elevation and corneal pharcymetric parameters among the four groups, except for front BFS, which was significantly different in blepharospasm groups (P < 0.05). Final D values were significantly higher in the severe blepharospasm (P < 0.01) group than that among controls. There were significant correlations between the blink rate and most corneal tomographic parameters. All parameters showed high reproducibility (ICC: 0.921–0.996) for normal and blepharospasm subjects. CONCLUSIONS: Blepharospasm may lead to a redistribution of the pressure applied by the lids over the cornea and, consequently, may result in corneal shape changes, which can be documented through corneal topography. BioMed Central 2018-09-05 /pmc/articles/PMC6126042/ /pubmed/30185154 http://dx.doi.org/10.1186/s12886-018-0897-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Huina
Zhou, Hongjie
Zhu, Tiepei
Ye, Juan
Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes
title Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes
title_full Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes
title_fullStr Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes
title_full_unstemmed Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes
title_short Evaluation of Scheimpflug imaging parameters in blepharospasm and normal eyes
title_sort evaluation of scheimpflug imaging parameters in blepharospasm and normal eyes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126042/
https://www.ncbi.nlm.nih.gov/pubmed/30185154
http://dx.doi.org/10.1186/s12886-018-0897-9
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