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Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren's Syndrome
CASE DESCRIPTION: A 72-year-old woman with primary Sjögren Syndrome (SS) was diagnosed during an inpatient hospital stay with dry symptoms. The patient had respiratory and constitutional symptoms, requiring a pulmonary imaging evaluation by high-resolution computed tomography (HRCT) of the thorax. C...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126109/ https://www.ncbi.nlm.nih.gov/pubmed/30210893 http://dx.doi.org/10.1155/2018/9745935 |
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author | Gómez Correa, Gustavo Adolfo Osorno Serna, Jovani Cáceres Acosta, Manuel Felipe Cáceres González, Juan David Calle Ramirez, Jaime Andrés Sandoval Mesa, Juan Paulo Roldán Pérez, Miguel Ignacio |
author_facet | Gómez Correa, Gustavo Adolfo Osorno Serna, Jovani Cáceres Acosta, Manuel Felipe Cáceres González, Juan David Calle Ramirez, Jaime Andrés Sandoval Mesa, Juan Paulo Roldán Pérez, Miguel Ignacio |
author_sort | Gómez Correa, Gustavo Adolfo |
collection | PubMed |
description | CASE DESCRIPTION: A 72-year-old woman with primary Sjögren Syndrome (SS) was diagnosed during an inpatient hospital stay with dry symptoms. The patient had respiratory and constitutional symptoms, requiring a pulmonary imaging evaluation by high-resolution computed tomography (HRCT) of the thorax. CLINICAL FINDINGS: Multiple cavitary pulmonary nodules, halo sign, and focal areas of ground-glass opacity with predominance in both bases were found in the images. Complementary studies were done where a neoplastic focus was ruled out. The diagnosis of nodular pulmonary amyloidosis was confirmed with a pulmonary biopsy performed by videothoracoscopy for histopathological study, which reported the formation of nodules in the parenchyma with amyloid deposits and positive immunohistochemical markers for CD3, CD20, and CD38 lymphocytic infiltration. TREATMENT AND OUTCOME: Initial inpatient management with intravenous cyclophosphamide and methylprednisolone was given. Subsequent outpatient management was given with high dose glucocorticoids. CLINICAL RELEVANCE: We presented a case of nodular pulmonary amyloidosis in a female patient with primary SS, which is a rare pulmonary manifestation of this syndrome. |
format | Online Article Text |
id | pubmed-6126109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61261092018-09-12 Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren's Syndrome Gómez Correa, Gustavo Adolfo Osorno Serna, Jovani Cáceres Acosta, Manuel Felipe Cáceres González, Juan David Calle Ramirez, Jaime Andrés Sandoval Mesa, Juan Paulo Roldán Pérez, Miguel Ignacio Case Rep Pulmonol Case Report CASE DESCRIPTION: A 72-year-old woman with primary Sjögren Syndrome (SS) was diagnosed during an inpatient hospital stay with dry symptoms. The patient had respiratory and constitutional symptoms, requiring a pulmonary imaging evaluation by high-resolution computed tomography (HRCT) of the thorax. CLINICAL FINDINGS: Multiple cavitary pulmonary nodules, halo sign, and focal areas of ground-glass opacity with predominance in both bases were found in the images. Complementary studies were done where a neoplastic focus was ruled out. The diagnosis of nodular pulmonary amyloidosis was confirmed with a pulmonary biopsy performed by videothoracoscopy for histopathological study, which reported the formation of nodules in the parenchyma with amyloid deposits and positive immunohistochemical markers for CD3, CD20, and CD38 lymphocytic infiltration. TREATMENT AND OUTCOME: Initial inpatient management with intravenous cyclophosphamide and methylprednisolone was given. Subsequent outpatient management was given with high dose glucocorticoids. CLINICAL RELEVANCE: We presented a case of nodular pulmonary amyloidosis in a female patient with primary SS, which is a rare pulmonary manifestation of this syndrome. Hindawi 2018-08-13 /pmc/articles/PMC6126109/ /pubmed/30210893 http://dx.doi.org/10.1155/2018/9745935 Text en Copyright © 2018 Gustavo Adolfo Gómez Correa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Gómez Correa, Gustavo Adolfo Osorno Serna, Jovani Cáceres Acosta, Manuel Felipe Cáceres González, Juan David Calle Ramirez, Jaime Andrés Sandoval Mesa, Juan Paulo Roldán Pérez, Miguel Ignacio Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren's Syndrome |
title | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren's Syndrome |
title_full | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren's Syndrome |
title_fullStr | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren's Syndrome |
title_full_unstemmed | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren's Syndrome |
title_short | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren's Syndrome |
title_sort | nodular pulmonary amyloidosis: a manifestation of sjögren's syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126109/ https://www.ncbi.nlm.nih.gov/pubmed/30210893 http://dx.doi.org/10.1155/2018/9745935 |
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