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Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications
In addition to changes in motor and sensory function, individuals with spinal cord injury (SCI) experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly obse...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126132/ https://www.ncbi.nlm.nih.gov/pubmed/30127106 http://dx.doi.org/10.4103/1673-5374.237112 |
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author | Herman, Paige E. Bloom, Ona |
author_facet | Herman, Paige E. Bloom, Ona |
author_sort | Herman, Paige E. |
collection | PubMed |
description | In addition to changes in motor and sensory function, individuals with spinal cord injury (SCI) experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardiovascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to improve immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genomics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI. |
format | Online Article Text |
id | pubmed-6126132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61261322018-09-12 Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications Herman, Paige E. Bloom, Ona Neural Regen Res Review In addition to changes in motor and sensory function, individuals with spinal cord injury (SCI) experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardiovascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to improve immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genomics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI. Medknow Publications & Media Pvt Ltd 2018-09 /pmc/articles/PMC6126132/ /pubmed/30127106 http://dx.doi.org/10.4103/1673-5374.237112 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Herman, Paige E. Bloom, Ona Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications |
title | Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications |
title_full | Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications |
title_fullStr | Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications |
title_full_unstemmed | Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications |
title_short | Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications |
title_sort | altered leukocyte gene expression after traumatic spinal cord injury: clinical implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126132/ https://www.ncbi.nlm.nih.gov/pubmed/30127106 http://dx.doi.org/10.4103/1673-5374.237112 |
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