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Utilizing zebrafish and okadaic acid to study Alzheimer’s disease

Despite the many years of extensive research using rodent models to study Alzheimer’s disease (AD), no cure or disease halting drug exists. An increasing number of people are suffering from the disease and a therapeutic intervention is needed. Therefore, it is necessary to have complementary models...

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Detalles Bibliográficos
Autores principales: Koehler, Daniel, Williams, Frederick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126137/
https://www.ncbi.nlm.nih.gov/pubmed/30127109
http://dx.doi.org/10.4103/1673-5374.237111
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author Koehler, Daniel
Williams, Frederick E.
author_facet Koehler, Daniel
Williams, Frederick E.
author_sort Koehler, Daniel
collection PubMed
description Despite the many years of extensive research using rodent models to study Alzheimer’s disease (AD), no cure or disease halting drug exists. An increasing number of people are suffering from the disease and a therapeutic intervention is needed. Therefore, it is necessary to have complementary models to aid in the drug discovery. The zebrafish animal model is emerging as a valuable model for the investigation of AD and neurodegenerative drug discovery. The main genes involved in human AD have homologous counterparts in zebrafish and have conserved function. The basic brain structure of the zebrafish is also conserved when compared to the mammalian brain. Recently an AD model was established by administering okadaic acid to zebrafish. It was used to test the efficacy of a novel drug, lanthionine ketimine-5-ethyl ester, and to elucidate its mechanism of action. This demonstrated the ability of the okadaic acid-induced AD zebrafish model to be implemented in the drug discovery process for therapeutics against AD.
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spelling pubmed-61261372018-09-12 Utilizing zebrafish and okadaic acid to study Alzheimer’s disease Koehler, Daniel Williams, Frederick E. Neural Regen Res Review Despite the many years of extensive research using rodent models to study Alzheimer’s disease (AD), no cure or disease halting drug exists. An increasing number of people are suffering from the disease and a therapeutic intervention is needed. Therefore, it is necessary to have complementary models to aid in the drug discovery. The zebrafish animal model is emerging as a valuable model for the investigation of AD and neurodegenerative drug discovery. The main genes involved in human AD have homologous counterparts in zebrafish and have conserved function. The basic brain structure of the zebrafish is also conserved when compared to the mammalian brain. Recently an AD model was established by administering okadaic acid to zebrafish. It was used to test the efficacy of a novel drug, lanthionine ketimine-5-ethyl ester, and to elucidate its mechanism of action. This demonstrated the ability of the okadaic acid-induced AD zebrafish model to be implemented in the drug discovery process for therapeutics against AD. Medknow Publications & Media Pvt Ltd 2018-09 /pmc/articles/PMC6126137/ /pubmed/30127109 http://dx.doi.org/10.4103/1673-5374.237111 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Koehler, Daniel
Williams, Frederick E.
Utilizing zebrafish and okadaic acid to study Alzheimer’s disease
title Utilizing zebrafish and okadaic acid to study Alzheimer’s disease
title_full Utilizing zebrafish and okadaic acid to study Alzheimer’s disease
title_fullStr Utilizing zebrafish and okadaic acid to study Alzheimer’s disease
title_full_unstemmed Utilizing zebrafish and okadaic acid to study Alzheimer’s disease
title_short Utilizing zebrafish and okadaic acid to study Alzheimer’s disease
title_sort utilizing zebrafish and okadaic acid to study alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126137/
https://www.ncbi.nlm.nih.gov/pubmed/30127109
http://dx.doi.org/10.4103/1673-5374.237111
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