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Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies
Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS), produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS can damage macromolecules such as proteins and lipids and leads to cell autophagy, apoptosis, and necrosis to the cells. Th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126224/ https://www.ncbi.nlm.nih.gov/pubmed/30276293 http://dx.doi.org/10.4103/2394-8108.195279 |
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author | Li, Wenjun Yang, Shaohua |
author_facet | Li, Wenjun Yang, Shaohua |
author_sort | Li, Wenjun |
collection | PubMed |
description | Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS), produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS can damage macromolecules such as proteins and lipids and leads to cell autophagy, apoptosis, and necrosis to the cells. This review describes studies on the generation of ROS, its role in the pathogenesis of ischemic stroke, and recent development in therapeutic strategies in reducing oxidative stress after ischemic stroke. |
format | Online Article Text |
id | pubmed-6126224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61262242018-10-01 Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies Li, Wenjun Yang, Shaohua Brain Circ Review Article Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS), produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS can damage macromolecules such as proteins and lipids and leads to cell autophagy, apoptosis, and necrosis to the cells. This review describes studies on the generation of ROS, its role in the pathogenesis of ischemic stroke, and recent development in therapeutic strategies in reducing oxidative stress after ischemic stroke. Medknow Publications & Media Pvt Ltd 2016 2016-12-06 /pmc/articles/PMC6126224/ /pubmed/30276293 http://dx.doi.org/10.4103/2394-8108.195279 Text en Copyright: © 2016 Brain Circulation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Li, Wenjun Yang, Shaohua Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
title | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
title_full | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
title_fullStr | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
title_full_unstemmed | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
title_short | Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies |
title_sort | targeting oxidative stress for the treatment of ischemic stroke: upstream and downstream therapeutic strategies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126224/ https://www.ncbi.nlm.nih.gov/pubmed/30276293 http://dx.doi.org/10.4103/2394-8108.195279 |
work_keys_str_mv | AT liwenjun targetingoxidativestressforthetreatmentofischemicstrokeupstreamanddownstreamtherapeuticstrategies AT yangshaohua targetingoxidativestressforthetreatmentofischemicstrokeupstreamanddownstreamtherapeuticstrategies |