Targeting G protein-coupled receptor for pain management

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Great progress has been made in understanding the important roles of various G protein-coupled receptors in the regulation of pain transmission. However, man...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Hongyan, Wang, Rong, Lu, Yinying, Xu, Xuehua, Ni, Jiaxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126263/
https://www.ncbi.nlm.nih.gov/pubmed/30276310
http://dx.doi.org/10.4103/bc.bc_3_17
_version_ 1783353306756677632
author Li, Hongyan
Wang, Rong
Lu, Yinying
Xu, Xuehua
Ni, Jiaxiang
author_facet Li, Hongyan
Wang, Rong
Lu, Yinying
Xu, Xuehua
Ni, Jiaxiang
author_sort Li, Hongyan
collection PubMed
description Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Great progress has been made in understanding the important roles of various G protein-coupled receptors in the regulation of pain transmission. However, many important questions remain uncertain about the precise signal transduction mechanisms. This review focuses opioid receptor and CXC receptor 4 on the effects and mechanisms of pain. Taken together, chemokines and their receptors are potential targets for the development of novel pain management and therapy.
format Online
Article
Text
id pubmed-6126263
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-61262632018-10-01 Targeting G protein-coupled receptor for pain management Li, Hongyan Wang, Rong Lu, Yinying Xu, Xuehua Ni, Jiaxiang Brain Circ Review Article Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Great progress has been made in understanding the important roles of various G protein-coupled receptors in the regulation of pain transmission. However, many important questions remain uncertain about the precise signal transduction mechanisms. This review focuses opioid receptor and CXC receptor 4 on the effects and mechanisms of pain. Taken together, chemokines and their receptors are potential targets for the development of novel pain management and therapy. Medknow Publications & Media Pvt Ltd 2017 2017-07-18 /pmc/articles/PMC6126263/ /pubmed/30276310 http://dx.doi.org/10.4103/bc.bc_3_17 Text en Copyright: © 2017 Brain Circulation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Li, Hongyan
Wang, Rong
Lu, Yinying
Xu, Xuehua
Ni, Jiaxiang
Targeting G protein-coupled receptor for pain management
title Targeting G protein-coupled receptor for pain management
title_full Targeting G protein-coupled receptor for pain management
title_fullStr Targeting G protein-coupled receptor for pain management
title_full_unstemmed Targeting G protein-coupled receptor for pain management
title_short Targeting G protein-coupled receptor for pain management
title_sort targeting g protein-coupled receptor for pain management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126263/
https://www.ncbi.nlm.nih.gov/pubmed/30276310
http://dx.doi.org/10.4103/bc.bc_3_17
work_keys_str_mv AT lihongyan targetinggproteincoupledreceptorforpainmanagement
AT wangrong targetinggproteincoupledreceptorforpainmanagement
AT luyinying targetinggproteincoupledreceptorforpainmanagement
AT xuxuehua targetinggproteincoupledreceptorforpainmanagement
AT nijiaxiang targetinggproteincoupledreceptorforpainmanagement

Ejemplares similares