Encapsulation of the HSP-90 Chaperone Inhibitor 17-AAG in Stable Liposome Allow Increasing the Therapeutic Index as Assessed, in vitro, on Leishmania (L) amazonensis Amastigotes-Hosted in Mouse CBA Macrophages

The current long-term treatment for leishmaniasis causes severe side effects and resistance in some cases. An evaluation of the anti-leishmanial potential of an HSP90-inhibitor, 17-allylamino-17-demethoxygeldanamycin (17-AAG), demonstrated its potent effect against Leishmania spp. in vitro and in vi...

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Detalles Bibliográficos
Autores principales: Petersen, Antonio Luis de Oliveira Almeida, Campos, Thiers A., Dantas, Diana Angélica dos Santos, Rebouças, Juliana de Souza, da Silva, Juliana Cruz, de Menezes, Juliana P. B., Formiga, Fábio R., de Melo, Janaina V., Machado, Giovanna, Veras, Patrícia S. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126448/
https://www.ncbi.nlm.nih.gov/pubmed/30214897
http://dx.doi.org/10.3389/fcimb.2018.00303

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