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Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway

PURPOSE: To examine the effects and mechanism of action of fasudil on cytoskeletal polymerization, collagen synthesis, and apoptosis in fibroblasts derived from human urethral scar tissue. MATERIALS AND METHODS: Fibroblasts treated with or without transforming growth factor β1 (TGF-β1, 10 ng/mL) wer...

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Detalles Bibliográficos
Autores principales:	Li, Xiao-Dong, Wu, Yu-Peng, Chen, Shao-Hao, Liang, Ying-Chun, Lin, Ting-Ting, Lin, Tian, Wei, Yong, Xue, Xue-Yi, Zheng, Qing-Shui, Xu, Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126504/ https://www.ncbi.nlm.nih.gov/pubmed/30214158 http://dx.doi.org/10.2147/DDDT.S156095

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