Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Mutations in the clk-1 gene impair mitochondrial ubiquinone biosynthesis and extend the lifespan in Caenorhabditis elegans. We demonstrate here that this life extension is linked to the repression of cytoplasmic mRNA translation, independent of the alleged nuclear form of CLK-1. Clk-1 mutations inhi...

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Detalles Bibliográficos
Autores principales: Molenaars, Marte, Janssens, Georges E, Santermans, Toon, Lezzerini, Marco, Jelier, Rob, MacInnes, Alyson W, Houtkooper, Riekelt H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126614/
https://www.ncbi.nlm.nih.gov/pubmed/30198021
http://dx.doi.org/10.26508/lsa.201800082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126614/
https://www.ncbi.nlm.nih.gov/pubmed/30198021
http://dx.doi.org/10.26508/lsa.201800082

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