Cargando…
Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation
Mutations in the clk-1 gene impair mitochondrial ubiquinone biosynthesis and extend the lifespan in Caenorhabditis elegans. We demonstrate here that this life extension is linked to the repression of cytoplasmic mRNA translation, independent of the alleged nuclear form of CLK-1. Clk-1 mutations inhi...
Autores principales: | Molenaars, Marte, Janssens, Georges E, Santermans, Toon, Lezzerini, Marco, Jelier, Rob, MacInnes, Alyson W, Houtkooper, Riekelt H |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126614/ https://www.ncbi.nlm.nih.gov/pubmed/30198021 http://dx.doi.org/10.26508/lsa.201800082 |
Ejemplares similares
-
Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion
por: Liu, Yasmine J., et al.
Publicado: (2019) -
Identification of longevity compounds with minimized probabilities of side effects
por: Janssens, Georges E., et al.
Publicado: (2020) -
From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs
por: McIntyre, Rebecca L, et al.
Publicado: (2019) -
Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction
por: van der Rijt, Sanne, et al.
Publicado: (2020) -
A uniparental isodisomy event introducing homozygous pathogenic variants drives a multisystem metabolic disorder
por: Daniels, Eileen G., et al.
Publicado: (2019)