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RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair

Unrestrained 53BP1 activity at DNA double-strand breaks (DSBs) hampers DNA end resection and upsets DSB repair pathway choice. RNF169 acts as a molecular rheostat to limit 53BP1 deposition at DSBs, but how this fine balance translates to DSB repair control remains undefined. In striking contrast to...

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Detalles Bibliográficos
Autores principales:	An, Liwei, Dong, Chao, Li, Junshi, Chen, Jie, Yuan, Jingsong, Huang, Jun, Chan, Kui Ming, Yu, Cheng-han, Huen, Michael S. Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126738/ https://www.ncbi.nlm.nih.gov/pubmed/30104380 http://dx.doi.org/10.1073/pnas.1804823115

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