Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis

Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful comparative model for human melanoma, but little is known about its genetic etiology. We mapped the genomic landscape of canine melanoma through multi-platform analysis of 37 tumors (31 mucosal, 3 acral, 2 cu...

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Detalles Bibliográficos
Autores principales: Hendricks, William P. D., Zismann, Victoria, Sivaprakasam, Karthigayini, Legendre, Christophe, Poorman, Kelsey, Tembe, Waibhav, Perdigones, Nieves, Kiefer, Jeffrey, Liang, Winnie, DeLuca, Valerie, Stark, Mitchell, Ruhe, Alison, Froman, Roe, Duesbery, Nicholas S., Washington, Megan, Aldrich, Jessica, Neff, Mark W., Huentelman, Matthew J., Hayward, Nicholas, Brown, Kevin, Thamm, Douglas, Post, Gerald, Khanna, Chand, Davis, Barbara, Breen, Matthew, Sekulic, Alexander, Trent, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126841/
https://www.ncbi.nlm.nih.gov/pubmed/30188888
http://dx.doi.org/10.1371/journal.pgen.1007589

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