Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication

Chronic activation of the immune system in HIV infection is one of the strongest predictors of morbidity and mortality. As such, approaches that reduce immune activation have received considerable interest. Previously, we demonstrated that administration of a type I interferon receptor antagonist (I...

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Detalles Bibliográficos
Autores principales: Nganou-Makamdop, Krystelle, Billingsley, James M., Yaffe, Zachary, O’Connor, Gregory, Tharp, Gregory K., Ransier, Amy, Laboune, Farida, Matus-Nicodemos, Rodrigo, Lerner, Andrea, Gharu, Lavina, Robertson, Jennifer M., Ford, Mandy L., Schlapschy, Martin, Kuhn, Nadine, Lensch, Alexandra, Lifson, Jeffrey, Nason, Martha, Skerra, Arne, Schreiber, Gideon, Bosinger, Steven E., Douek, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126880/
https://www.ncbi.nlm.nih.gov/pubmed/30142226
http://dx.doi.org/10.1371/journal.ppat.1007246

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