Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here we find that keratinocytes and other human cells mount an innate immune response within hours of etoposide-induced DNA damage, which involves the DNA sensing adaptor STING but is independent of the cy...

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Detalles Bibliográficos
Autores principales: Dunphy, Gillian, Flannery, Sinéad M., Almine, Jessica F., Connolly, Dympna J., Paulus, Christina, Jønsson, Kasper L., Jakobsen, Martin R., Nevels, Michael M., Bowie, Andrew G., Unterholzner, Leonie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127031/
https://www.ncbi.nlm.nih.gov/pubmed/30193098
http://dx.doi.org/10.1016/j.molcel.2018.07.034

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