The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma

Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK(+) and ALK(–) anaplastic large cell lymphoma (ALCL). Here we demonstrate high-level BATF and BATF3 expression in ALCL. Both BATFs bind classical AP-1 motifs and interact with in ALCL deregulated AP-1 fac...

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Detalles Bibliográficos
Autores principales: Schleussner, Nikolai, Merkel, Olaf, Costanza, Mariantonia, Liang, Huan-Chang, Hummel, Franziska, Romagnani, Chiara, Durek, Pawel, Anagnostopoulos, Ioannis, Hummel, Michael, Jöhrens, Korinna, Niedobitek, Antonia, Griffin, Patrick R., Piva, Roberto, Sczakiel, Henrike L., Woessmann, Wilhelm, Damm-Welk, Christine, Hinze, Christian, Stoiber, Dagmar, Gillissen, Bernd, Turner, Suzanne D., Kaergel, Eva, von Hoff, Linda, Grau, Michael, Lenz, Georg, Dörken, Bernd, Scheidereit, Claus, Kenner, Lukas, Janz, Martin, Mathas, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127090/
https://www.ncbi.nlm.nih.gov/pubmed/29588546
http://dx.doi.org/10.1038/s41375-018-0045-9

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