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The biological significance of histone modifiers in multiple myeloma: clinical applications
Multiple myeloma (MM) is a clonal plasma cell disorder that is characterized by a variety of genetic alterations. Recent studies have highlighted not only the importance of these genetic events but also epigenetic aberrations including DNA methylation, histone modifications, and non-coding RNAs in t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127133/ https://www.ncbi.nlm.nih.gov/pubmed/30190472 http://dx.doi.org/10.1038/s41408-018-0119-y |
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author | Ohguchi, Hiroto Hideshima, Teru Anderson, Kenneth C. |
author_facet | Ohguchi, Hiroto Hideshima, Teru Anderson, Kenneth C. |
author_sort | Ohguchi, Hiroto |
collection | PubMed |
description | Multiple myeloma (MM) is a clonal plasma cell disorder that is characterized by a variety of genetic alterations. Recent studies have highlighted not only the importance of these genetic events but also epigenetic aberrations including DNA methylation, histone modifications, and non-coding RNAs in the biology of MM. Post-translational modifications of histone, such as methylation and acetylation, contribute to chromatin dynamics, and are modulated by histone modifying enzymes, and dysregulation of these enzymes is implicated in the pathogenesis of cancers, including MM. Histone modifiers also have non-histone substrates and enzymatically independent roles, which are also involved in tumorigenesis. Here we review and provide comprehensive insight into the biologic significance of histone methyl- and acetyl-modifiers in MM, and further provide an overview of the clinical applications of histone modifier inhibitors, especially histone deacetylase inhibitors. These findings underline the emerging roles of histone modifiers in the pathogenesis of MM, and further highlight the possibility of novel epigenetic therapies in MM. |
format | Online Article Text |
id | pubmed-6127133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61271332018-09-07 The biological significance of histone modifiers in multiple myeloma: clinical applications Ohguchi, Hiroto Hideshima, Teru Anderson, Kenneth C. Blood Cancer J Review Article Multiple myeloma (MM) is a clonal plasma cell disorder that is characterized by a variety of genetic alterations. Recent studies have highlighted not only the importance of these genetic events but also epigenetic aberrations including DNA methylation, histone modifications, and non-coding RNAs in the biology of MM. Post-translational modifications of histone, such as methylation and acetylation, contribute to chromatin dynamics, and are modulated by histone modifying enzymes, and dysregulation of these enzymes is implicated in the pathogenesis of cancers, including MM. Histone modifiers also have non-histone substrates and enzymatically independent roles, which are also involved in tumorigenesis. Here we review and provide comprehensive insight into the biologic significance of histone methyl- and acetyl-modifiers in MM, and further provide an overview of the clinical applications of histone modifier inhibitors, especially histone deacetylase inhibitors. These findings underline the emerging roles of histone modifiers in the pathogenesis of MM, and further highlight the possibility of novel epigenetic therapies in MM. Nature Publishing Group UK 2018-08-22 /pmc/articles/PMC6127133/ /pubmed/30190472 http://dx.doi.org/10.1038/s41408-018-0119-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Ohguchi, Hiroto Hideshima, Teru Anderson, Kenneth C. The biological significance of histone modifiers in multiple myeloma: clinical applications |
title | The biological significance of histone modifiers in multiple myeloma: clinical applications |
title_full | The biological significance of histone modifiers in multiple myeloma: clinical applications |
title_fullStr | The biological significance of histone modifiers in multiple myeloma: clinical applications |
title_full_unstemmed | The biological significance of histone modifiers in multiple myeloma: clinical applications |
title_short | The biological significance of histone modifiers in multiple myeloma: clinical applications |
title_sort | biological significance of histone modifiers in multiple myeloma: clinical applications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127133/ https://www.ncbi.nlm.nih.gov/pubmed/30190472 http://dx.doi.org/10.1038/s41408-018-0119-y |
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