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Langevin equation in complex media and anomalous diffusion

The problem of biological motion is a very intriguing and topical issue. Many efforts are being focused on the development of novel modelling approaches for the description of anomalous diffusion in biological systems, such as the very complex and heterogeneous cell environment. Nevertheless, many q...

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Detalles Bibliográficos
Autores principales: Vitali, Silvia, Sposini, Vittoria, Sliusarenko, Oleksii, Paradisi, Paolo, Castellani, Gastone, Pagnini, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127165/
https://www.ncbi.nlm.nih.gov/pubmed/30158182
http://dx.doi.org/10.1098/rsif.2018.0282
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author Vitali, Silvia
Sposini, Vittoria
Sliusarenko, Oleksii
Paradisi, Paolo
Castellani, Gastone
Pagnini, Gianni
author_facet Vitali, Silvia
Sposini, Vittoria
Sliusarenko, Oleksii
Paradisi, Paolo
Castellani, Gastone
Pagnini, Gianni
author_sort Vitali, Silvia
collection PubMed
description The problem of biological motion is a very intriguing and topical issue. Many efforts are being focused on the development of novel modelling approaches for the description of anomalous diffusion in biological systems, such as the very complex and heterogeneous cell environment. Nevertheless, many questions are still open, such as the joint manifestation of statistical features in agreement with different models that can also be somewhat alternative to each other, e.g. continuous time random walk and fractional Brownian motion. To overcome these limitations, we propose a stochastic diffusion model with additive noise and linear friction force (linear Langevin equation), thus involving the explicit modelling of velocity dynamics. The complexity of the medium is parametrized via a population of intensity parameters (relaxation time and diffusivity of velocity), thus introducing an additional randomness, in addition to white noise, in the particle's dynamics. We prove that, for proper distributions of these parameters, we can get both Gaussian anomalous diffusion, fractional diffusion and its generalizations.
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spelling pubmed-61271652018-09-07 Langevin equation in complex media and anomalous diffusion Vitali, Silvia Sposini, Vittoria Sliusarenko, Oleksii Paradisi, Paolo Castellani, Gastone Pagnini, Gianni J R Soc Interface Life Sciences–Physics interface The problem of biological motion is a very intriguing and topical issue. Many efforts are being focused on the development of novel modelling approaches for the description of anomalous diffusion in biological systems, such as the very complex and heterogeneous cell environment. Nevertheless, many questions are still open, such as the joint manifestation of statistical features in agreement with different models that can also be somewhat alternative to each other, e.g. continuous time random walk and fractional Brownian motion. To overcome these limitations, we propose a stochastic diffusion model with additive noise and linear friction force (linear Langevin equation), thus involving the explicit modelling of velocity dynamics. The complexity of the medium is parametrized via a population of intensity parameters (relaxation time and diffusivity of velocity), thus introducing an additional randomness, in addition to white noise, in the particle's dynamics. We prove that, for proper distributions of these parameters, we can get both Gaussian anomalous diffusion, fractional diffusion and its generalizations. The Royal Society 2018-08 2018-08-29 /pmc/articles/PMC6127165/ /pubmed/30158182 http://dx.doi.org/10.1098/rsif.2018.0282 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Life Sciences–Physics interface
Vitali, Silvia
Sposini, Vittoria
Sliusarenko, Oleksii
Paradisi, Paolo
Castellani, Gastone
Pagnini, Gianni
Langevin equation in complex media and anomalous diffusion
title Langevin equation in complex media and anomalous diffusion
title_full Langevin equation in complex media and anomalous diffusion
title_fullStr Langevin equation in complex media and anomalous diffusion
title_full_unstemmed Langevin equation in complex media and anomalous diffusion
title_short Langevin equation in complex media and anomalous diffusion
title_sort langevin equation in complex media and anomalous diffusion
topic Life Sciences–Physics interface
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127165/
https://www.ncbi.nlm.nih.gov/pubmed/30158182
http://dx.doi.org/10.1098/rsif.2018.0282
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