DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this translocation affects DISC1 function is incompletely understood. N-methyl-D-aspartate receptors (NMDAR) play a central role in synaptic plasticity a...

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Detalles Bibliográficos
Autores principales: Malavasi, Elise L. V., Economides, Kyriakos D., Grünewald, Ellen, Makedonopoulou, Paraskevi, Gautier, Philippe, Mackie, Shaun, Murphy, Laura C., Murdoch, Hannah, Crummie, Darragh, Ogawa, Fumiaki, McCartney, Daniel L., O’Sullivan, Shane T., Burr, Karen, Torrance, Helen S., Phillips, Jonathan, Bonneau, Marion, Anderson, Susan M., Perry, Paul, Pearson, Matthew, Constantinides, Costas, Davidson-Smith, Hazel, Kabiri, Mostafa, Duff, Barbara, Johnstone, Mandy, Polites, H. Greg, Lawrie, Stephen M., Blackwood, Douglas H., Semple, Colin A., Evans, Kathryn L., Didier, Michel, Chandran, Siddharthan, McIntosh, Andrew M., Price, David J., Houslay, Miles D., Porteous, David J., Millar, J. Kirsty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127284/
https://www.ncbi.nlm.nih.gov/pubmed/30190480
http://dx.doi.org/10.1038/s41398-018-0228-1

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