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Prefrontal Cortex Activity Predicts Mental Fatigue in Young and Elderly Men During a 2 h “Go/NoGo” Task

Background: Although the effects of mental fatigue on cognitive–motor function and psychological state in young adults are well-documented, its effects in the elderly are not completely understood. The aim of this study was to estimate the effect of prolonged cognitive load on the indicators of psyc...

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Autores principales: Terentjeviene, Asta, Maciuleviciene, Edita, Vadopalas, Kazys, Mickeviciene, Dalia, Karanauskiene, Diana, Valanciene, Dovile, Solianik, Rima, Emeljanovas, Arunas, Kamandulis, Sigitas, Skurvydas, Albertas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127290/
https://www.ncbi.nlm.nih.gov/pubmed/30233302
http://dx.doi.org/10.3389/fnins.2018.00620
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author Terentjeviene, Asta
Maciuleviciene, Edita
Vadopalas, Kazys
Mickeviciene, Dalia
Karanauskiene, Diana
Valanciene, Dovile
Solianik, Rima
Emeljanovas, Arunas
Kamandulis, Sigitas
Skurvydas, Albertas
author_facet Terentjeviene, Asta
Maciuleviciene, Edita
Vadopalas, Kazys
Mickeviciene, Dalia
Karanauskiene, Diana
Valanciene, Dovile
Solianik, Rima
Emeljanovas, Arunas
Kamandulis, Sigitas
Skurvydas, Albertas
author_sort Terentjeviene, Asta
collection PubMed
description Background: Although the effects of mental fatigue on cognitive–motor function and psychological state in young adults are well-documented, its effects in the elderly are not completely understood. The aim of this study was to estimate the effect of prolonged cognitive load on the indicators of psychological, cognitive, and motor functions. Methods: Fifteen young and 15 elderly men were asked to perform a 2 h “Go/NoGo” task. Psychological state (mood and motivation), cognitive (prefrontal cortex activity and cognitive performance), and motor (motor cortex excitability and grip strength) functions were measured before and after the task. During the 2 h task, both groups had a significantly similar increase in the number of “Incorrect NoGo” errors. Only in young men reaction time (RT) of “Incorrect NoGo” and intraindividual variability of RT of “Incorrect NoGo” significantly increased during task. After the task, handgrip strength decreased for the young men, whereas latency of motor evoked potentials prolonged both groups. Nevertheless, both groups indicated that they felt fatigue after the 2 h task; we observed that mental demand increased, whereas intrinsic motivation and mood decreased only in young men. Prolonged task decreased the switching/rest ratio of oxygenated hemoglobin for the young and the elderly men; however, greater for elderly than young men. Interestingly, the more the prefrontal cortex was activated before the 2 h task during the switching task, the fewer of “Incorrect NoGo” errors made by the young men and the greater the number of errors made by the elderly men. Conclusion: Because of the greater mental load and (possibly) greater activation of prefrontal cortex during the 2 h “Go/NoGo” task, there was greater mental and neuromuscular performance fatigue in young men than in elderly men.
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spelling pubmed-61272902018-09-19 Prefrontal Cortex Activity Predicts Mental Fatigue in Young and Elderly Men During a 2 h “Go/NoGo” Task Terentjeviene, Asta Maciuleviciene, Edita Vadopalas, Kazys Mickeviciene, Dalia Karanauskiene, Diana Valanciene, Dovile Solianik, Rima Emeljanovas, Arunas Kamandulis, Sigitas Skurvydas, Albertas Front Neurosci Neuroscience Background: Although the effects of mental fatigue on cognitive–motor function and psychological state in young adults are well-documented, its effects in the elderly are not completely understood. The aim of this study was to estimate the effect of prolonged cognitive load on the indicators of psychological, cognitive, and motor functions. Methods: Fifteen young and 15 elderly men were asked to perform a 2 h “Go/NoGo” task. Psychological state (mood and motivation), cognitive (prefrontal cortex activity and cognitive performance), and motor (motor cortex excitability and grip strength) functions were measured before and after the task. During the 2 h task, both groups had a significantly similar increase in the number of “Incorrect NoGo” errors. Only in young men reaction time (RT) of “Incorrect NoGo” and intraindividual variability of RT of “Incorrect NoGo” significantly increased during task. After the task, handgrip strength decreased for the young men, whereas latency of motor evoked potentials prolonged both groups. Nevertheless, both groups indicated that they felt fatigue after the 2 h task; we observed that mental demand increased, whereas intrinsic motivation and mood decreased only in young men. Prolonged task decreased the switching/rest ratio of oxygenated hemoglobin for the young and the elderly men; however, greater for elderly than young men. Interestingly, the more the prefrontal cortex was activated before the 2 h task during the switching task, the fewer of “Incorrect NoGo” errors made by the young men and the greater the number of errors made by the elderly men. Conclusion: Because of the greater mental load and (possibly) greater activation of prefrontal cortex during the 2 h “Go/NoGo” task, there was greater mental and neuromuscular performance fatigue in young men than in elderly men. Frontiers Media S.A. 2018-08-31 /pmc/articles/PMC6127290/ /pubmed/30233302 http://dx.doi.org/10.3389/fnins.2018.00620 Text en Copyright © 2018 Terentjeviene, Maciuleviciene, Vadopalas, Mickeviciene, Karanauskiene, Valanciene, Solianik, Emeljanovas, Kamandulis and Skurvydas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Terentjeviene, Asta
Maciuleviciene, Edita
Vadopalas, Kazys
Mickeviciene, Dalia
Karanauskiene, Diana
Valanciene, Dovile
Solianik, Rima
Emeljanovas, Arunas
Kamandulis, Sigitas
Skurvydas, Albertas
Prefrontal Cortex Activity Predicts Mental Fatigue in Young and Elderly Men During a 2 h “Go/NoGo” Task
title Prefrontal Cortex Activity Predicts Mental Fatigue in Young and Elderly Men During a 2 h “Go/NoGo” Task
title_full Prefrontal Cortex Activity Predicts Mental Fatigue in Young and Elderly Men During a 2 h “Go/NoGo” Task
title_fullStr Prefrontal Cortex Activity Predicts Mental Fatigue in Young and Elderly Men During a 2 h “Go/NoGo” Task
title_full_unstemmed Prefrontal Cortex Activity Predicts Mental Fatigue in Young and Elderly Men During a 2 h “Go/NoGo” Task
title_short Prefrontal Cortex Activity Predicts Mental Fatigue in Young and Elderly Men During a 2 h “Go/NoGo” Task
title_sort prefrontal cortex activity predicts mental fatigue in young and elderly men during a 2 h “go/nogo” task
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127290/
https://www.ncbi.nlm.nih.gov/pubmed/30233302
http://dx.doi.org/10.3389/fnins.2018.00620
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