Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells

Chemotherapeutic drugs have a common intent to activate apoptosis in tumor cells. However, master regulators of apoptosis (e.g., p53, p16/CDKN2A) are frequently genetically inactivated in cancers, resulting in multidrug resistance. An alternative, p53-independent method for terminating malignant pro...

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Detalles Bibliográficos
Autores principales: Enane, Francis O., Saunthararajah, Yogen, Korc, Murray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127320/
https://www.ncbi.nlm.nih.gov/pubmed/30190481
http://dx.doi.org/10.1038/s41419-018-0919-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127320/
https://www.ncbi.nlm.nih.gov/pubmed/30190481
http://dx.doi.org/10.1038/s41419-018-0919-9

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