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Specific PKC βII inhibitor: one stone two birds in the treatment of diabetic foot ulcers

To explore whether or not inhibition of protein kinase C βII (PKC βII) stimulates angiogenesis as well as prevents excessive NETosis in diabetics thus accelerating wound healing. Streptozotocin (STZ, 60 mg/kg/day for 5 days, i.p.) was injected to induce type I diabetes in male ICR mice. Mice were tr...

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Detalles Bibliográficos
Autores principales: Das, Sushant Kumar, Yuan, Yi Feng, Li, Mao Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127666/
https://www.ncbi.nlm.nih.gov/pubmed/29440456
http://dx.doi.org/10.1042/BSR20171459