The role and mechanism of chaperones Calnexin/Calreticulin in which ALLN selectively rescues the trafficking defective of HERG-A561V mutation

Long QT (LQT) type 2 (LQT2) is caused by HERG mutation. L539fs/47 encodes a truncated protein, and its mechanisms in HERG mutation are unknown. HERG mutation plasmids were overexpressed in HEK293T cells, respectively, followed by analyzing lysates with Western blot. Transfected HEK293T cells were tr...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Shen, Tingting, Fang, Peiliang, Zhou, Junbo, Lou, Kenan, Cen, Zemin, Qian, Hai, Zhou, Jianqing, Liu, Ningsheng, Lian, Jiangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127669/
https://www.ncbi.nlm.nih.gov/pubmed/29752336
http://dx.doi.org/10.1042/BSR20171269

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