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LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21
As a newly discovered long non-coding RNA, small nucleolar RNA host gene 3 (SHNG3) has been reported to be dysregulated in certain cancers. Nevertheless, the details about clinical values and biological effects of SNHG3 on glioma are still covered. In this paper, we determined the expression level o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127675/ https://www.ncbi.nlm.nih.gov/pubmed/30042166 http://dx.doi.org/10.1042/BSR20180420 |
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author | Fei, Fan He, Yongsheng He, Sen He, Zhongze Wang, Youyu Wu, Gang Li, Mengni |
author_facet | Fei, Fan He, Yongsheng He, Sen He, Zhongze Wang, Youyu Wu, Gang Li, Mengni |
author_sort | Fei, Fan |
collection | PubMed |
description | As a newly discovered long non-coding RNA, small nucleolar RNA host gene 3 (SHNG3) has been reported to be dysregulated in certain cancers. Nevertheless, the details about clinical values and biological effects of SNHG3 on glioma are still covered. In this paper, we determined the expression level of SNHG3 in glioma tissues and cells and evaluated the effect of SNHG3 expression on the prognosis of glioma patients. The functional assays were applied to define the effects of SNHG3 on the biological behaviors in glioma including cell proliferation, cell cycle, and apoptosis. It was revealed that SNHG3 was much more enriched in glioma tissues and cell lines than in normal ones. Furthermore, gain- or loss-of-function experiments indicated that the up-regulation of SNHG3 promoted cell proliferation, accelerate cell cycle progress, and repressed cell apoptosis. The mechanistic assays disclosed that SNHG3 facilitated the malignant progression of glioma through epigenetically repressing KLF2 and p21 via recruiting enhancer of zeste homolog 2 to the promoter of KLF2 and p21. Generally, it was exposed that SNHG3 might function as an oncogene in glioma and could be explored as a potential prognostic biomarker and therapeutic target for glioma. |
format | Online Article Text |
id | pubmed-6127675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61276752018-09-11 LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21 Fei, Fan He, Yongsheng He, Sen He, Zhongze Wang, Youyu Wu, Gang Li, Mengni Biosci Rep Research Articles As a newly discovered long non-coding RNA, small nucleolar RNA host gene 3 (SHNG3) has been reported to be dysregulated in certain cancers. Nevertheless, the details about clinical values and biological effects of SNHG3 on glioma are still covered. In this paper, we determined the expression level of SNHG3 in glioma tissues and cells and evaluated the effect of SNHG3 expression on the prognosis of glioma patients. The functional assays were applied to define the effects of SNHG3 on the biological behaviors in glioma including cell proliferation, cell cycle, and apoptosis. It was revealed that SNHG3 was much more enriched in glioma tissues and cell lines than in normal ones. Furthermore, gain- or loss-of-function experiments indicated that the up-regulation of SNHG3 promoted cell proliferation, accelerate cell cycle progress, and repressed cell apoptosis. The mechanistic assays disclosed that SNHG3 facilitated the malignant progression of glioma through epigenetically repressing KLF2 and p21 via recruiting enhancer of zeste homolog 2 to the promoter of KLF2 and p21. Generally, it was exposed that SNHG3 might function as an oncogene in glioma and could be explored as a potential prognostic biomarker and therapeutic target for glioma. Portland Press Ltd. 2018-09-07 /pmc/articles/PMC6127675/ /pubmed/30042166 http://dx.doi.org/10.1042/BSR20180420 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Fei, Fan He, Yongsheng He, Sen He, Zhongze Wang, Youyu Wu, Gang Li, Mengni LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21 |
title | LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21 |
title_full | LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21 |
title_fullStr | LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21 |
title_full_unstemmed | LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21 |
title_short | LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21 |
title_sort | lncrna snhg3 enhances the malignant progress of glioma through silencing klf2 and p21 |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127675/ https://www.ncbi.nlm.nih.gov/pubmed/30042166 http://dx.doi.org/10.1042/BSR20180420 |
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