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Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate)
Trimethyl citrate, C(9)H(14)O(7) (systematic name: trimethyl 2-hydroxypropane-1,2,3-tricarboxylate), 2, was prepared by the esterification of citric acid and methanol in the presence of thionyl chloride at 273 K. The bond lengths and angles in 2 compare closely with those observed in citric acid...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127686/ https://www.ncbi.nlm.nih.gov/pubmed/30225132 http://dx.doi.org/10.1107/S2056989018011222 |
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author | Morjan, Rami Y. El-Kurdi, Said M. Azarah, Jannat N. Eleiwa, Neda A. Abu-Teim, Omar S. Awadallah, Adel M. Raftery, James Gardiner, John M. |
author_facet | Morjan, Rami Y. El-Kurdi, Said M. Azarah, Jannat N. Eleiwa, Neda A. Abu-Teim, Omar S. Awadallah, Adel M. Raftery, James Gardiner, John M. |
author_sort | Morjan, Rami Y. |
collection | PubMed |
description | Trimethyl citrate, C(9)H(14)O(7) (systematic name: trimethyl 2-hydroxypropane-1,2,3-tricarboxylate), 2, was prepared by the esterification of citric acid and methanol in the presence of thionyl chloride at 273 K. The bond lengths and angles in 2 compare closely with those observed in citric acid. The C—C bonds adjacent to the terminal carboxyl groups are significantly shorter than those around the central C atom. The central carboxylate group and the hydroxy group occur in the normal planar arrangement with an r.m.s. deviation of 0.0171 Å from the mean plane involving all six atoms in the central unit. The crystal structure is almost completely dominated by the formation of inversion dimers through an O—H⋯O hydrogen bond, together with an extensive array of weaker C—H⋯O contacts. These generate a three-dimensional network structure with molecules stacked along the c-axis direction. |
format | Online Article Text |
id | pubmed-6127686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-61276862018-09-17 Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate) Morjan, Rami Y. El-Kurdi, Said M. Azarah, Jannat N. Eleiwa, Neda A. Abu-Teim, Omar S. Awadallah, Adel M. Raftery, James Gardiner, John M. Acta Crystallogr E Crystallogr Commun Research Communications Trimethyl citrate, C(9)H(14)O(7) (systematic name: trimethyl 2-hydroxypropane-1,2,3-tricarboxylate), 2, was prepared by the esterification of citric acid and methanol in the presence of thionyl chloride at 273 K. The bond lengths and angles in 2 compare closely with those observed in citric acid. The C—C bonds adjacent to the terminal carboxyl groups are significantly shorter than those around the central C atom. The central carboxylate group and the hydroxy group occur in the normal planar arrangement with an r.m.s. deviation of 0.0171 Å from the mean plane involving all six atoms in the central unit. The crystal structure is almost completely dominated by the formation of inversion dimers through an O—H⋯O hydrogen bond, together with an extensive array of weaker C—H⋯O contacts. These generate a three-dimensional network structure with molecules stacked along the c-axis direction. International Union of Crystallography 2018-08-24 /pmc/articles/PMC6127686/ /pubmed/30225132 http://dx.doi.org/10.1107/S2056989018011222 Text en © Morjan et al. 2018 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/2.0/uk/ |
spellingShingle | Research Communications Morjan, Rami Y. El-Kurdi, Said M. Azarah, Jannat N. Eleiwa, Neda A. Abu-Teim, Omar S. Awadallah, Adel M. Raftery, James Gardiner, John M. Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate) |
title | Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate) |
title_full | Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate) |
title_fullStr | Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate) |
title_full_unstemmed | Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate) |
title_short | Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate) |
title_sort | inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hydroxypropane-1,2,3-tricarboxylate) |
topic | Research Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127686/ https://www.ncbi.nlm.nih.gov/pubmed/30225132 http://dx.doi.org/10.1107/S2056989018011222 |
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