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Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate)

Trimethyl citrate, C(9)H(14)O(7) (systematic name: trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate), 2, was prepared by the esterification of citric acid and methanol in the presence of thionyl chloride at 273 K. The bond lengths and angles in 2 compare closely with those observed in citric acid...

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Autores principales: Morjan, Rami Y., El-Kurdi, Said M., Azarah, Jannat N., Eleiwa, Neda A., Abu-Teim, Omar S., Awadallah, Adel M., Raftery, James, Gardiner, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127686/
https://www.ncbi.nlm.nih.gov/pubmed/30225132
http://dx.doi.org/10.1107/S2056989018011222
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author Morjan, Rami Y.
El-Kurdi, Said M.
Azarah, Jannat N.
Eleiwa, Neda A.
Abu-Teim, Omar S.
Awadallah, Adel M.
Raftery, James
Gardiner, John M.
author_facet Morjan, Rami Y.
El-Kurdi, Said M.
Azarah, Jannat N.
Eleiwa, Neda A.
Abu-Teim, Omar S.
Awadallah, Adel M.
Raftery, James
Gardiner, John M.
author_sort Morjan, Rami Y.
collection PubMed
description Trimethyl citrate, C(9)H(14)O(7) (systematic name: trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate), 2, was prepared by the esterification of citric acid and methanol in the presence of thionyl chloride at 273 K. The bond lengths and angles in 2 compare closely with those observed in citric acid. The C—C bonds adjacent to the terminal carboxyl groups are significantly shorter than those around the central C atom. The central carboxyl­ate group and the hy­droxy group occur in the normal planar arrangement with an r.m.s. deviation of 0.0171 Å from the mean plane involving all six atoms in the central unit. The crystal structure is almost completely dominated by the formation of inversion dimers through an O—H⋯O hydrogen bond, together with an extensive array of weaker C—H⋯O contacts. These generate a three-dimensional network structure with mol­ecules stacked along the c-axis direction.
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spelling pubmed-61276862018-09-17 Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate) Morjan, Rami Y. El-Kurdi, Said M. Azarah, Jannat N. Eleiwa, Neda A. Abu-Teim, Omar S. Awadallah, Adel M. Raftery, James Gardiner, John M. Acta Crystallogr E Crystallogr Commun Research Communications Trimethyl citrate, C(9)H(14)O(7) (systematic name: trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate), 2, was prepared by the esterification of citric acid and methanol in the presence of thionyl chloride at 273 K. The bond lengths and angles in 2 compare closely with those observed in citric acid. The C—C bonds adjacent to the terminal carboxyl groups are significantly shorter than those around the central C atom. The central carboxyl­ate group and the hy­droxy group occur in the normal planar arrangement with an r.m.s. deviation of 0.0171 Å from the mean plane involving all six atoms in the central unit. The crystal structure is almost completely dominated by the formation of inversion dimers through an O—H⋯O hydrogen bond, together with an extensive array of weaker C—H⋯O contacts. These generate a three-dimensional network structure with mol­ecules stacked along the c-axis direction. International Union of Crystallography 2018-08-24 /pmc/articles/PMC6127686/ /pubmed/30225132 http://dx.doi.org/10.1107/S2056989018011222 Text en © Morjan et al. 2018 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/2.0/uk/
spellingShingle Research Communications
Morjan, Rami Y.
El-Kurdi, Said M.
Azarah, Jannat N.
Eleiwa, Neda A.
Abu-Teim, Omar S.
Awadallah, Adel M.
Raftery, James
Gardiner, John M.
Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate)
title Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate)
title_full Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate)
title_fullStr Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate)
title_full_unstemmed Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate)
title_short Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate)
title_sort inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate)
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127686/
https://www.ncbi.nlm.nih.gov/pubmed/30225132
http://dx.doi.org/10.1107/S2056989018011222
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