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Crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus
‘Nitrogen mustard’ bis(2-chloroethyl)amine derivatives (2R,4S,5R)- and (2S,4S,5R)-2-[bis(2-chloroethyl)amino]-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one (2a and 2b, respectively), C(14)H(21)Cl(2)N(2)O(2)P, and (2R,4R)- and (2S,4R)-2-[bis(2-chloroethyl)amino]-4-isobutyl-1,3,2-ox...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127709/ https://www.ncbi.nlm.nih.gov/pubmed/30225127 http://dx.doi.org/10.1107/S2056989018011349 |
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author | Rohde Jr, Laurence N. Zeller, Matthias Jackson, John A. |
author_facet | Rohde Jr, Laurence N. Zeller, Matthias Jackson, John A. |
author_sort | Rohde Jr, Laurence N. |
collection | PubMed |
description | ‘Nitrogen mustard’ bis(2-chloroethyl)amine derivatives (2R,4S,5R)- and (2S,4S,5R)-2-[bis(2-chloroethyl)amino]-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one (2a and 2b, respectively), C(14)H(21)Cl(2)N(2)O(2)P, and (2R,4R)- and (2S,4R)-2-[bis(2-chloroethyl)amino]-4-isobutyl-1,3,2-oxazaphospholidin-2-one (3a and 3b, respectively), C(10)H(21)Cl(2)N(2)O(2)P, were synthesized as a mixture of diastereomers through a 1:1 reaction of enantiomerically pure chiral amino alcohols with bis(2-chloroethyl)phosphoramidic dichloride. Flash column chromatography yielded diastereomerically pure products, as supported by (31)P NMR. The crystal structures of 2b and 3b were obtained to determine their absolute configuration at phosphorus, and (31)P NMR chemical shift trends are proposed based on the spatial relationship of the bis(2-chloroethyl)amine moiety and the chiral substituent of the amino alcohol. Oxazaphospholidinones were observed to have a more downfield (31)P NMR chemical shift when the aforementioned substituents are in a syn configuration and vice versa for when they are anti. |
format | Online Article Text |
id | pubmed-6127709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-61277092018-09-17 Crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus Rohde Jr, Laurence N. Zeller, Matthias Jackson, John A. Acta Crystallogr E Crystallogr Commun Research Communications ‘Nitrogen mustard’ bis(2-chloroethyl)amine derivatives (2R,4S,5R)- and (2S,4S,5R)-2-[bis(2-chloroethyl)amino]-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one (2a and 2b, respectively), C(14)H(21)Cl(2)N(2)O(2)P, and (2R,4R)- and (2S,4R)-2-[bis(2-chloroethyl)amino]-4-isobutyl-1,3,2-oxazaphospholidin-2-one (3a and 3b, respectively), C(10)H(21)Cl(2)N(2)O(2)P, were synthesized as a mixture of diastereomers through a 1:1 reaction of enantiomerically pure chiral amino alcohols with bis(2-chloroethyl)phosphoramidic dichloride. Flash column chromatography yielded diastereomerically pure products, as supported by (31)P NMR. The crystal structures of 2b and 3b were obtained to determine their absolute configuration at phosphorus, and (31)P NMR chemical shift trends are proposed based on the spatial relationship of the bis(2-chloroethyl)amine moiety and the chiral substituent of the amino alcohol. Oxazaphospholidinones were observed to have a more downfield (31)P NMR chemical shift when the aforementioned substituents are in a syn configuration and vice versa for when they are anti. International Union of Crystallography 2018-08-24 /pmc/articles/PMC6127709/ /pubmed/30225127 http://dx.doi.org/10.1107/S2056989018011349 Text en © Rohde Jr et al. 2018 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/2.0/uk/ |
spellingShingle | Research Communications Rohde Jr, Laurence N. Zeller, Matthias Jackson, John A. Crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus |
title | Crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus |
title_full | Crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus |
title_fullStr | Crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus |
title_full_unstemmed | Crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus |
title_short | Crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus |
title_sort | crystal structures of chiral 2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphospholidin-2-one derivatives for the absolute configuration at phosphorus |
topic | Research Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127709/ https://www.ncbi.nlm.nih.gov/pubmed/30225127 http://dx.doi.org/10.1107/S2056989018011349 |
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