Mol­ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ(6),1-benzo­thia­zine-3-carboxyl­ate

The title compound, C(11)H(11)NO(4)S, possesses weak analgesic properties and is a source compound for the synthesis of highly active analgesic and anti-inflammatory compounds. The benzo­thia­zine ring adopts a conformation intermediate between twist-boat and sofa. The ester substituent is turned to...

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Autores principales: Shishkina, Svitlana, Ukrainets, Igor, Hamza, Ganna, Grinevich, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127716/
https://www.ncbi.nlm.nih.gov/pubmed/30225121
http://dx.doi.org/10.1107/S2056989018011362
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author Shishkina, Svitlana
Ukrainets, Igor
Hamza, Ganna
Grinevich, Lina
author_facet Shishkina, Svitlana
Ukrainets, Igor
Hamza, Ganna
Grinevich, Lina
author_sort Shishkina, Svitlana
collection PubMed
description The title compound, C(11)H(11)NO(4)S, possesses weak analgesic properties and is a source compound for the synthesis of highly active analgesic and anti-inflammatory compounds. The benzo­thia­zine ring adopts a conformation intermediate between twist-boat and sofa. The ester substituent is turned towards the endocyclic double bond because of steric repulsion. In the crystal, the mol­ecules form columns along the [001] direction, bound by N—H⋯O hydrogen bonds and stacking inter­actions.
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spelling pubmed-61277162018-09-17 Mol­ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ(6),1-benzo­thia­zine-3-carboxyl­ate Shishkina, Svitlana Ukrainets, Igor Hamza, Ganna Grinevich, Lina Acta Crystallogr E Crystallogr Commun Research Communications The title compound, C(11)H(11)NO(4)S, possesses weak analgesic properties and is a source compound for the synthesis of highly active analgesic and anti-inflammatory compounds. The benzo­thia­zine ring adopts a conformation intermediate between twist-boat and sofa. The ester substituent is turned towards the endocyclic double bond because of steric repulsion. In the crystal, the mol­ecules form columns along the [001] direction, bound by N—H⋯O hydrogen bonds and stacking inter­actions. International Union of Crystallography 2018-08-21 /pmc/articles/PMC6127716/ /pubmed/30225121 http://dx.doi.org/10.1107/S2056989018011362 Text en © Shishkina et al. 2018 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/2.0/uk/
spellingShingle Research Communications
Shishkina, Svitlana
Ukrainets, Igor
Hamza, Ganna
Grinevich, Lina
Mol­ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ(6),1-benzo­thia­zine-3-carboxyl­ate
title Mol­ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ(6),1-benzo­thia­zine-3-carboxyl­ate
title_full Mol­ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ(6),1-benzo­thia­zine-3-carboxyl­ate
title_fullStr Mol­ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ(6),1-benzo­thia­zine-3-carboxyl­ate
title_full_unstemmed Mol­ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ(6),1-benzo­thia­zine-3-carboxyl­ate
title_short Mol­ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ(6),1-benzo­thia­zine-3-carboxyl­ate
title_sort mol­ecular and crystal structure of methyl 4-methyl-2,2-dioxo-1h-2λ(6),1-benzo­thia­zine-3-carboxyl­ate
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127716/
https://www.ncbi.nlm.nih.gov/pubmed/30225121
http://dx.doi.org/10.1107/S2056989018011362
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