An active DNA-based nanoprobe for photoacoustic pH imaging

We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a prom...

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Detalles Bibliográficos
Autores principales: Baumann, Kevin N., Fux, Alexandra C., Joseph, James, Bohndiek, Sarah E., Hernández-Ainsa, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127833/
https://www.ncbi.nlm.nih.gov/pubmed/30137064
http://dx.doi.org/10.1039/c8cc04007a
Descripción
Sumario:We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.

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