An active DNA-based nanoprobe for photoacoustic pH imaging

We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a prom...

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Detalles Bibliográficos
Autores principales: Baumann, Kevin N., Fux, Alexandra C., Joseph, James, Bohndiek, Sarah E., Hernández-Ainsa, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127833/
https://www.ncbi.nlm.nih.gov/pubmed/30137064
http://dx.doi.org/10.1039/c8cc04007a
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author Baumann, Kevin N.
Fux, Alexandra C.
Joseph, James
Bohndiek, Sarah E.
Hernández-Ainsa, Silvia
author_facet Baumann, Kevin N.
Fux, Alexandra C.
Joseph, James
Bohndiek, Sarah E.
Hernández-Ainsa, Silvia
author_sort Baumann, Kevin N.
collection PubMed
description We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.
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spelling pubmed-61278332018-09-12 An active DNA-based nanoprobe for photoacoustic pH imaging Baumann, Kevin N. Fux, Alexandra C. Joseph, James Bohndiek, Sarah E. Hernández-Ainsa, Silvia Chem Commun (Camb) Chemistry We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA. Royal Society of Chemistry 2018-09-16 2018-08-23 /pmc/articles/PMC6127833/ /pubmed/30137064 http://dx.doi.org/10.1039/c8cc04007a Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Baumann, Kevin N.
Fux, Alexandra C.
Joseph, James
Bohndiek, Sarah E.
Hernández-Ainsa, Silvia
An active DNA-based nanoprobe for photoacoustic pH imaging
title An active DNA-based nanoprobe for photoacoustic pH imaging
title_full An active DNA-based nanoprobe for photoacoustic pH imaging
title_fullStr An active DNA-based nanoprobe for photoacoustic pH imaging
title_full_unstemmed An active DNA-based nanoprobe for photoacoustic pH imaging
title_short An active DNA-based nanoprobe for photoacoustic pH imaging
title_sort active dna-based nanoprobe for photoacoustic ph imaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127833/
https://www.ncbi.nlm.nih.gov/pubmed/30137064
http://dx.doi.org/10.1039/c8cc04007a
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