Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors

Protein tyrosine phosphatase 1B (PTP1B) is an attractive molecular target for anti-diabetes, anti-obesity, and anti-cancer drug development. From the seeds of Silybum marianum, nine flavonolignans, namely, silybins A, B (1, 2), isosilybins A, B (3, 4), silychristins A, B (5, 6), isosilychristin A (7...

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Detalles Bibliográficos
Autores principales: Qin, Ningbo, Sasaki, Tatsunori, Li, Wei, Wang, Jian, Zhang, Xiangyu, Li, Dahong, Li, Zhanlin, Cheng, Maosheng, Hua, Huiming, Koike, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127842/
https://www.ncbi.nlm.nih.gov/pubmed/30160205
http://dx.doi.org/10.1080/14756366.2018.1497020

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