Reduced MEK inhibition preserves genomic stability in naïve human ES cells

Human embryonic stem cells (hESCs) can be captured in a primed state resembling the postimplantation epiblast or in a naïve state resembling the preimplantation epiblast. Naïve conditions allow the study of preimplantation development ex vivo but reportedly lead to chromosomal abnormalities, comprom...

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Detalles Bibliográficos
Autores principales: Stefano, Bruno Di, Ueda, Mai, Sabri, Shan, Brumbaugh, Justin, Huebner, Aaron J., Sahakyan, Anna, Clement, Kendell, Clowers, Katie J., Erickson, Alison R., Shioda, Keiko, Gygi, Steven P., Gu, Hongcang, Shioda, Toshi, Meissner, Alexander, Takashima, Yasuhiro, Plath, Kathrin, Hochedlinger, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127858/
https://www.ncbi.nlm.nih.gov/pubmed/30127506
http://dx.doi.org/10.1038/s41592-018-0104-1

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