Cargando…

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

The centrosomal protein, CEP55, is a key regulator of cytokinesis, and its overexpression is linked to genomic instability, a hallmark of cancer. However, the mechanism by which it mediates genomic instability remains elusive. Here, we showed that CEP55 overexpression/knockdown impacts survival of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C, Duijf, Pascal HG, Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M, Lakhani, Sunil R, López, J Alejandro, Spring, Kevin J, Timpson, Paul, Gabrielli, Brian, Waddell, Nicola, Khanna, Kum Kum
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127888/ https://www.ncbi.nlm.nih.gov/pubmed/30108112 http://dx.doi.org/10.15252/emmm.201708566

Ejemplares similares

Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8(+) T-cells infiltration in triple-negative breast cancer
por: Kalimutho, Murugan, et al.
Publicado: (2019)

Cep55 overexpression promotes genomic instability and tumorigenesis in mice
por: Sinha, Debottam, et al.
Publicado: (2020)

CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer
por: Makhale, Ashwini, et al.
Publicado: (2021)

Enhanced dependency of KRAS‐mutant colorectal cancer cells on RAD51‐dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae
por: Kalimutho, Murugan, et al.
Publicado: (2017)

The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells
por: Anderson, Alison M., et al.
Publicado: (2017)

CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors
por: Lu, Xue, et al.
Publicado: (2022)

Targeting BRF2 in Cancer Using Repurposed Drugs
por: Rashidieh, Behnam, et al.
Publicado: (2021)

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition
por: Raninga, Prahlad V., et al.
Publicado: (2020)

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis
por: Rashidieh, Behnam, et al.
Publicado: (2021)

COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis
por: Hancock, Janelle L., et al.
Publicado: (2023)

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival
por: Cabrera, Elisa, et al.
Publicado: (2019)

Complexities of pharmacogenomic interactions in cancer
por: Khanna, Kum Kum, et al.
Publicado: (2020)

Complex-based analysis of dysregulated cellular processes in cancer
por: Srihari, Sriganesh, et al.
Publicado: (2014)

Importance of the CEP215-Pericentrin Interaction for Centrosome Maturation during Mitosis
por: Kim, Seongjae, et al.
Publicado: (2014)

Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma
por: Sze, Jun Hui, et al.
Publicado: (2019)

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy
por: Liu, Chao, et al.
Publicado: (2014)

Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer
por: Al-Ejeh, Fares, et al.
Publicado: (2014)

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib
por: Bessette, Darrell C., et al.
Publicado: (2015)

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines
por: Momeny, Majid, et al.
Publicado: (2015)

Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?
por: Lakhani, Sunil R, et al.
Publicado: (2010)

A truncating mutation in CEP55 is the likely cause of MARCH, a novel syndrome affecting neuronal mitosis
por: Frosk, Patrick, et al.
Publicado: (2017)

Emerging Biomarkers for Diagnosis, Prevention and Treatment of Brain Metastases—From Biology to Clinical Utility
por: Kalita-de Croft, Priyakshi, et al.
Publicado: (2022)

Molecular Aspects of Breast Cancer Metastasis to the Brain
por: Saunus, Jodi M., et al.
Publicado: (2011)

Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos
por: Wilkinson, Christopher J, et al.
Publicado: (2009)

Cep63 and Cep152 Cooperate to Ensure Centriole Duplication
por: Brown, Nicola J., et al.
Publicado: (2013)

Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context
por: Saunus, Jodi M., et al.
Publicado: (2017)

Low baseline pulmonary levels of cytotoxic lymphocytes as a predisposing risk factor for severe COVID-19
por: Duijf, Pascal H.G.
Publicado: (2020)

Cross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for Cancer
por: Raninga, Prahlad V., et al.
Publicado: (2014)

RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC
por: Kim, Seong-Jin, et al.
Publicado: (2020)

CEP19 cooperates with FOP and CEP350 to drive early steps in the ciliogenesis programme
por: Mojarad, Bahareh A., et al.
Publicado: (2017)

Cross-talk between two antioxidants, thioredoxin reductase and heme oxygenase-1, and therapeutic implications for multiple myeloma
por: Raninga, Prahlad V., et al.
Publicado: (2016)

Temporal dynamics of protein complexes in PPI Networks: a case study using yeast cell cycle dynamics
por: Srihari, Sriganesh, et al.
Publicado: (2012)

Proteomic Analysis of the Breast Cancer Brain Metastasis Microenvironment
por: Kalita-de Croft, Priyakshi, et al.
Publicado: (2019)

Soft QCD and CEP at LHCb
por: Giubega, Lavinia-Elena
Publicado: (2019)

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
por: Rashidieh, Behnam, et al.
Publicado: (2023)

Aggresome assembly at the centrosome is driven by CP110–CEP97–CEP290 and centriolar satellites
por: Prosser, Suzanna L., et al.
Publicado: (2022)

Landscape of Epidermal Growth Factor Receptor Heterodimers in Brain Metastases
por: Lim, Malcolm, et al.
Publicado: (2022)

The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium
por: Stowe, Timothy R., et al.
Publicado: (2012)

The APC/C targets the Cep152–Cep63 complex at the centrosome to regulate mitotic spindle assembly
por: Tischer, Thomas, et al.
Publicado: (2022)

Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?
por: Chin, Venessa T., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_o2qeuah660u4k9q63tgkfo0m53