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Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo
BACKGROUND: Sickle Cell Anemia (SCA) is characterized by high levels of oxidative stress markers and low levels of antioxidant capacity. Antioxidant defence mechanisms against the harmful effects of ROS requires cellular and extracellular enzymes. These enzymes requires micronutrient for complete ac...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127910/ https://www.ncbi.nlm.nih.gov/pubmed/30202531 http://dx.doi.org/10.1186/s12878-018-0118-z |
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author | Mukuku, Olivier Sungu, Joseph K. Mutombo, Augustin Mulangu Mawaw, Paul Makan Aloni, Michel Ntetani Wembonyama, Stanislas Okitotsho Luboya, Oscar Numbi |
author_facet | Mukuku, Olivier Sungu, Joseph K. Mutombo, Augustin Mulangu Mawaw, Paul Makan Aloni, Michel Ntetani Wembonyama, Stanislas Okitotsho Luboya, Oscar Numbi |
author_sort | Mukuku, Olivier |
collection | PubMed |
description | BACKGROUND: Sickle Cell Anemia (SCA) is characterized by high levels of oxidative stress markers and low levels of antioxidant capacity. Antioxidant defence mechanisms against the harmful effects of ROS requires cellular and extracellular enzymes. These enzymes requires micronutrient for complete activity. Information on micronutrients such as manganese, cobalt and copper in SCA population was poorly documented in the literature. METHODS: Plasma copper, manganese, cobalt and albumin concentrations determined by atomic absorption spectrophotometry were compared between two groups of children: 76 with SCA (Hb-SS) and 76 without SCA (controls). This study was conducted in the Muhona Hospital of Kasumbalesa, which is situated in a rural and low in resources. RESULTS: The mean age was 10.0 years (SD = 5.4) in SCA children and 9.2 years (SD = 4.7) in the control group. The levels of cobalt, manganese, copper and albumin were not different between the two groups (p > 0.05). CONCLUSION: In our study, albumin, manganese, cobalt and copper values did not differ between SCA children in steady state and Hb-AA children. The lack of differences in plasma elemental concentrations between the two groups in context of increased demands in the SCA group, may represent adequate compensatory intake or elemental dyshomeostasis in the SCA group. |
format | Online Article Text |
id | pubmed-6127910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61279102018-09-10 Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo Mukuku, Olivier Sungu, Joseph K. Mutombo, Augustin Mulangu Mawaw, Paul Makan Aloni, Michel Ntetani Wembonyama, Stanislas Okitotsho Luboya, Oscar Numbi BMC Hematol Research Article BACKGROUND: Sickle Cell Anemia (SCA) is characterized by high levels of oxidative stress markers and low levels of antioxidant capacity. Antioxidant defence mechanisms against the harmful effects of ROS requires cellular and extracellular enzymes. These enzymes requires micronutrient for complete activity. Information on micronutrients such as manganese, cobalt and copper in SCA population was poorly documented in the literature. METHODS: Plasma copper, manganese, cobalt and albumin concentrations determined by atomic absorption spectrophotometry were compared between two groups of children: 76 with SCA (Hb-SS) and 76 without SCA (controls). This study was conducted in the Muhona Hospital of Kasumbalesa, which is situated in a rural and low in resources. RESULTS: The mean age was 10.0 years (SD = 5.4) in SCA children and 9.2 years (SD = 4.7) in the control group. The levels of cobalt, manganese, copper and albumin were not different between the two groups (p > 0.05). CONCLUSION: In our study, albumin, manganese, cobalt and copper values did not differ between SCA children in steady state and Hb-AA children. The lack of differences in plasma elemental concentrations between the two groups in context of increased demands in the SCA group, may represent adequate compensatory intake or elemental dyshomeostasis in the SCA group. BioMed Central 2018-09-06 /pmc/articles/PMC6127910/ /pubmed/30202531 http://dx.doi.org/10.1186/s12878-018-0118-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Mukuku, Olivier Sungu, Joseph K. Mutombo, Augustin Mulangu Mawaw, Paul Makan Aloni, Michel Ntetani Wembonyama, Stanislas Okitotsho Luboya, Oscar Numbi Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo |
title | Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo |
title_full | Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo |
title_fullStr | Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo |
title_full_unstemmed | Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo |
title_short | Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo |
title_sort | albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at kasumbalesa, in democratic republic of congo |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127910/ https://www.ncbi.nlm.nih.gov/pubmed/30202531 http://dx.doi.org/10.1186/s12878-018-0118-z |
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