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Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study
PURPOSE: This study was designed to retrospectively analyze the safety and efficacy of chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma. METHODS AND MATERIALS: Eligible patients were aged 76 years or older, had a histopathologic di...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127966/ https://www.ncbi.nlm.nih.gov/pubmed/30197939 http://dx.doi.org/10.1016/j.adro.2018.02.010 |
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author | Watanabe, Akinori Katada, Chikatoshi Komori, Shouko Moriya, Hiromitsu Yamashita, Keishi Harada, Hiroki Azuma, Mizutomo Kondo, Yuki Kubota, Yo Furue, Yasuaki Kawanishi, Natsuko Yamane, Sakiko Wada, Takuya Yano, Takafumi Ishido, Kenji Tanabe, Satoshi Hayakawa, Kazushige Koizumi, Wasaburo |
author_facet | Watanabe, Akinori Katada, Chikatoshi Komori, Shouko Moriya, Hiromitsu Yamashita, Keishi Harada, Hiroki Azuma, Mizutomo Kondo, Yuki Kubota, Yo Furue, Yasuaki Kawanishi, Natsuko Yamane, Sakiko Wada, Takuya Yano, Takafumi Ishido, Kenji Tanabe, Satoshi Hayakawa, Kazushige Koizumi, Wasaburo |
author_sort | Watanabe, Akinori |
collection | PubMed |
description | PURPOSE: This study was designed to retrospectively analyze the safety and efficacy of chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma. METHODS AND MATERIALS: Eligible patients were aged 76 years or older, had a histopathologic diagnosis of esophageal squamous cell carcinoma, and were treated at the Kitasato University Hospital between January 2010 and March 2016. Chemotherapy consisted of nedaplatin in an intravenous dose of 90 mg/m(2) on day 1 and 5-fluorouracil in an intravenous dose of 800 mg/m(2) on days 1 to 5, repeated every 4 weeks for 2 cycles. Radiation therapy consisted of 50.4 Gy in 28 fractions for thoracic tumors and 61.2 Gy for cervical tumors. RESULTS: Twenty-five patients were studied. Patient characteristics were as follows: median age 79 years (range, 76-85 years), clinical stage I/II/III/IV (7/8/8/2, respectively), and surgically resectable/unresectable (17/8, respectively). The completion rates of radiation therapy and chemoradiation therapy were 100% and 84%, respectively. Grade ≥3 acute toxicities included neutropenia (76%), leukopenia (72%), thrombocytopenia (32%), anemia (28%), anorexia (32%), oral mucositis (20%), febrile neutropenia (12%), and esophagitis (8%). Grade ≥3 late toxicities included esophageal stenosis (12%) and pleural effusion (4%). The complete response rate was 64%. In the median follow-up period of 18.9 months, the 1-year overall survival rate was 68%. CONCLUSIONS: Definitive chemoradiation therapy with nedaplatin and 5-fluorouracil may be a feasible treatment option for elderly patients with esophageal squamous cell carcinoma. |
format | Online Article Text |
id | pubmed-6127966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-61279662018-09-07 Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study Watanabe, Akinori Katada, Chikatoshi Komori, Shouko Moriya, Hiromitsu Yamashita, Keishi Harada, Hiroki Azuma, Mizutomo Kondo, Yuki Kubota, Yo Furue, Yasuaki Kawanishi, Natsuko Yamane, Sakiko Wada, Takuya Yano, Takafumi Ishido, Kenji Tanabe, Satoshi Hayakawa, Kazushige Koizumi, Wasaburo Adv Radiat Oncol Gastrointestinal Cancer PURPOSE: This study was designed to retrospectively analyze the safety and efficacy of chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma. METHODS AND MATERIALS: Eligible patients were aged 76 years or older, had a histopathologic diagnosis of esophageal squamous cell carcinoma, and were treated at the Kitasato University Hospital between January 2010 and March 2016. Chemotherapy consisted of nedaplatin in an intravenous dose of 90 mg/m(2) on day 1 and 5-fluorouracil in an intravenous dose of 800 mg/m(2) on days 1 to 5, repeated every 4 weeks for 2 cycles. Radiation therapy consisted of 50.4 Gy in 28 fractions for thoracic tumors and 61.2 Gy for cervical tumors. RESULTS: Twenty-five patients were studied. Patient characteristics were as follows: median age 79 years (range, 76-85 years), clinical stage I/II/III/IV (7/8/8/2, respectively), and surgically resectable/unresectable (17/8, respectively). The completion rates of radiation therapy and chemoradiation therapy were 100% and 84%, respectively. Grade ≥3 acute toxicities included neutropenia (76%), leukopenia (72%), thrombocytopenia (32%), anemia (28%), anorexia (32%), oral mucositis (20%), febrile neutropenia (12%), and esophagitis (8%). Grade ≥3 late toxicities included esophageal stenosis (12%) and pleural effusion (4%). The complete response rate was 64%. In the median follow-up period of 18.9 months, the 1-year overall survival rate was 68%. CONCLUSIONS: Definitive chemoradiation therapy with nedaplatin and 5-fluorouracil may be a feasible treatment option for elderly patients with esophageal squamous cell carcinoma. Elsevier 2018-03-01 /pmc/articles/PMC6127966/ /pubmed/30197939 http://dx.doi.org/10.1016/j.adro.2018.02.010 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Gastrointestinal Cancer Watanabe, Akinori Katada, Chikatoshi Komori, Shouko Moriya, Hiromitsu Yamashita, Keishi Harada, Hiroki Azuma, Mizutomo Kondo, Yuki Kubota, Yo Furue, Yasuaki Kawanishi, Natsuko Yamane, Sakiko Wada, Takuya Yano, Takafumi Ishido, Kenji Tanabe, Satoshi Hayakawa, Kazushige Koizumi, Wasaburo Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
title | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
title_full | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
title_fullStr | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
title_full_unstemmed | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
title_short | Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study |
title_sort | feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: a retrospective study |
topic | Gastrointestinal Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127966/ https://www.ncbi.nlm.nih.gov/pubmed/30197939 http://dx.doi.org/10.1016/j.adro.2018.02.010 |
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