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Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study

PURPOSE: This study was designed to retrospectively analyze the safety and efficacy of chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma. METHODS AND MATERIALS: Eligible patients were aged 76 years or older, had a histopathologic di...

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Autores principales: Watanabe, Akinori, Katada, Chikatoshi, Komori, Shouko, Moriya, Hiromitsu, Yamashita, Keishi, Harada, Hiroki, Azuma, Mizutomo, Kondo, Yuki, Kubota, Yo, Furue, Yasuaki, Kawanishi, Natsuko, Yamane, Sakiko, Wada, Takuya, Yano, Takafumi, Ishido, Kenji, Tanabe, Satoshi, Hayakawa, Kazushige, Koizumi, Wasaburo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127966/
https://www.ncbi.nlm.nih.gov/pubmed/30197939
http://dx.doi.org/10.1016/j.adro.2018.02.010
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author Watanabe, Akinori
Katada, Chikatoshi
Komori, Shouko
Moriya, Hiromitsu
Yamashita, Keishi
Harada, Hiroki
Azuma, Mizutomo
Kondo, Yuki
Kubota, Yo
Furue, Yasuaki
Kawanishi, Natsuko
Yamane, Sakiko
Wada, Takuya
Yano, Takafumi
Ishido, Kenji
Tanabe, Satoshi
Hayakawa, Kazushige
Koizumi, Wasaburo
author_facet Watanabe, Akinori
Katada, Chikatoshi
Komori, Shouko
Moriya, Hiromitsu
Yamashita, Keishi
Harada, Hiroki
Azuma, Mizutomo
Kondo, Yuki
Kubota, Yo
Furue, Yasuaki
Kawanishi, Natsuko
Yamane, Sakiko
Wada, Takuya
Yano, Takafumi
Ishido, Kenji
Tanabe, Satoshi
Hayakawa, Kazushige
Koizumi, Wasaburo
author_sort Watanabe, Akinori
collection PubMed
description PURPOSE: This study was designed to retrospectively analyze the safety and efficacy of chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma. METHODS AND MATERIALS: Eligible patients were aged 76 years or older, had a histopathologic diagnosis of esophageal squamous cell carcinoma, and were treated at the Kitasato University Hospital between January 2010 and March 2016. Chemotherapy consisted of nedaplatin in an intravenous dose of 90 mg/m(2) on day 1 and 5-fluorouracil in an intravenous dose of 800 mg/m(2) on days 1 to 5, repeated every 4 weeks for 2 cycles. Radiation therapy consisted of 50.4 Gy in 28 fractions for thoracic tumors and 61.2 Gy for cervical tumors. RESULTS: Twenty-five patients were studied. Patient characteristics were as follows: median age 79 years (range, 76-85 years), clinical stage I/II/III/IV (7/8/8/2, respectively), and surgically resectable/unresectable (17/8, respectively). The completion rates of radiation therapy and chemoradiation therapy were 100% and 84%, respectively. Grade ≥3 acute toxicities included neutropenia (76%), leukopenia (72%), thrombocytopenia (32%), anemia (28%), anorexia (32%), oral mucositis (20%), febrile neutropenia (12%), and esophagitis (8%). Grade ≥3 late toxicities included esophageal stenosis (12%) and pleural effusion (4%). The complete response rate was 64%. In the median follow-up period of 18.9 months, the 1-year overall survival rate was 68%. CONCLUSIONS: Definitive chemoradiation therapy with nedaplatin and 5-fluorouracil may be a feasible treatment option for elderly patients with esophageal squamous cell carcinoma.
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spelling pubmed-61279662018-09-07 Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study Watanabe, Akinori Katada, Chikatoshi Komori, Shouko Moriya, Hiromitsu Yamashita, Keishi Harada, Hiroki Azuma, Mizutomo Kondo, Yuki Kubota, Yo Furue, Yasuaki Kawanishi, Natsuko Yamane, Sakiko Wada, Takuya Yano, Takafumi Ishido, Kenji Tanabe, Satoshi Hayakawa, Kazushige Koizumi, Wasaburo Adv Radiat Oncol Gastrointestinal Cancer PURPOSE: This study was designed to retrospectively analyze the safety and efficacy of chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma. METHODS AND MATERIALS: Eligible patients were aged 76 years or older, had a histopathologic diagnosis of esophageal squamous cell carcinoma, and were treated at the Kitasato University Hospital between January 2010 and March 2016. Chemotherapy consisted of nedaplatin in an intravenous dose of 90 mg/m(2) on day 1 and 5-fluorouracil in an intravenous dose of 800 mg/m(2) on days 1 to 5, repeated every 4 weeks for 2 cycles. Radiation therapy consisted of 50.4 Gy in 28 fractions for thoracic tumors and 61.2 Gy for cervical tumors. RESULTS: Twenty-five patients were studied. Patient characteristics were as follows: median age 79 years (range, 76-85 years), clinical stage I/II/III/IV (7/8/8/2, respectively), and surgically resectable/unresectable (17/8, respectively). The completion rates of radiation therapy and chemoradiation therapy were 100% and 84%, respectively. Grade ≥3 acute toxicities included neutropenia (76%), leukopenia (72%), thrombocytopenia (32%), anemia (28%), anorexia (32%), oral mucositis (20%), febrile neutropenia (12%), and esophagitis (8%). Grade ≥3 late toxicities included esophageal stenosis (12%) and pleural effusion (4%). The complete response rate was 64%. In the median follow-up period of 18.9 months, the 1-year overall survival rate was 68%. CONCLUSIONS: Definitive chemoradiation therapy with nedaplatin and 5-fluorouracil may be a feasible treatment option for elderly patients with esophageal squamous cell carcinoma. Elsevier 2018-03-01 /pmc/articles/PMC6127966/ /pubmed/30197939 http://dx.doi.org/10.1016/j.adro.2018.02.010 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Gastrointestinal Cancer
Watanabe, Akinori
Katada, Chikatoshi
Komori, Shouko
Moriya, Hiromitsu
Yamashita, Keishi
Harada, Hiroki
Azuma, Mizutomo
Kondo, Yuki
Kubota, Yo
Furue, Yasuaki
Kawanishi, Natsuko
Yamane, Sakiko
Wada, Takuya
Yano, Takafumi
Ishido, Kenji
Tanabe, Satoshi
Hayakawa, Kazushige
Koizumi, Wasaburo
Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study
title Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study
title_full Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study
title_fullStr Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study
title_full_unstemmed Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study
title_short Feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: A retrospective study
title_sort feasibility of definitive chemoradiation therapy with nedaplatin and 5-fluorouracil in elderly patients with esophageal squamous cell carcinoma: a retrospective study
topic Gastrointestinal Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127966/
https://www.ncbi.nlm.nih.gov/pubmed/30197939
http://dx.doi.org/10.1016/j.adro.2018.02.010
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