Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate

Ceramide pathway is a key regulator in cell proliferation and apoptosis and oxidative stress up-regulate ceramides. Acid ceramidase (ACDase), neutral sphingomyelinase (NSMase) and glucosylceramide synthase (GCS) are critical enzymatic systems in ceramide metabolism. Our data represent the comparativ...

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Autores principales: Boojar, Mahdi Mashhadi Akbar, Boojar, Masoud Mashhadi Akbar, Golmohammad, Sepide, Bahrehbar, Iraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Pharmacology, Toxicology and Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127980/
https://www.ncbi.nlm.nih.gov/pubmed/30197917
http://dx.doi.org/10.1016/j.dib.2018.08.065
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author Boojar, Mahdi Mashhadi Akbar
Boojar, Masoud Mashhadi Akbar
Golmohammad, Sepide
Bahrehbar, Iraj
author_facet Boojar, Mahdi Mashhadi Akbar
Boojar, Masoud Mashhadi Akbar
Golmohammad, Sepide
Bahrehbar, Iraj
author_sort Boojar, Mahdi Mashhadi Akbar
collection PubMed
description Ceramide pathway is a key regulator in cell proliferation and apoptosis and oxidative stress up-regulate ceramides. Acid ceramidase (ACDase), neutral sphingomyelinase (NSMase) and glucosylceramide synthase (GCS) are critical enzymatic systems in ceramide metabolism. Our data represent the comparative assessment of Hesperetin (Hst) and hesperetin-7-O-acetate (HTA) effects on A-494 renal carcinoma cells include cell survival, caspase-3 and 9 activities, total cellular ceramide and the activities of ACDase, NSMase, GCS and superoxide dismutase (SOD). Data reveals potentiating effects of both HTA and Hst on ceramide pathway and may offer a novel tool in human renal cell carcinoma therapy.
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spelling pubmed-61279802018-09-07 Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate Boojar, Mahdi Mashhadi Akbar Boojar, Masoud Mashhadi Akbar Golmohammad, Sepide Bahrehbar, Iraj Data Brief Pharmacology, Toxicology and Pharmaceutical Science Ceramide pathway is a key regulator in cell proliferation and apoptosis and oxidative stress up-regulate ceramides. Acid ceramidase (ACDase), neutral sphingomyelinase (NSMase) and glucosylceramide synthase (GCS) are critical enzymatic systems in ceramide metabolism. Our data represent the comparative assessment of Hesperetin (Hst) and hesperetin-7-O-acetate (HTA) effects on A-494 renal carcinoma cells include cell survival, caspase-3 and 9 activities, total cellular ceramide and the activities of ACDase, NSMase, GCS and superoxide dismutase (SOD). Data reveals potentiating effects of both HTA and Hst on ceramide pathway and may offer a novel tool in human renal cell carcinoma therapy. Elsevier 2018-08-29 /pmc/articles/PMC6127980/ /pubmed/30197917 http://dx.doi.org/10.1016/j.dib.2018.08.065 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Pharmacology, Toxicology and Pharmaceutical Science
Boojar, Mahdi Mashhadi Akbar
Boojar, Masoud Mashhadi Akbar
Golmohammad, Sepide
Bahrehbar, Iraj
Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate
title Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate
title_full Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate
title_fullStr Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate
title_full_unstemmed Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate
title_short Data on cell survival, apoptosis, ceramide metabolism and oxidative stress in A-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-O-acetate
title_sort data on cell survival, apoptosis, ceramide metabolism and oxidative stress in a-494 renal cell carcinoma cell line treated with hesperetin and hesperetin-7-o-acetate
topic Pharmacology, Toxicology and Pharmaceutical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127980/
https://www.ncbi.nlm.nih.gov/pubmed/30197917
http://dx.doi.org/10.1016/j.dib.2018.08.065
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