Fetal—Not Maternal—APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry

Black Americans are at increased risk for preeclampsia. Genetic variants in apolipoprotein L1 (APOL1) account for much of the increased risk for kidney disease in blacks. APOL1 is expressed in human placenta and transgenic mice expressing APOL1 develop preeclampsia. We evaluated the role of APOL1 va...

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Detalles Bibliográficos
Autores principales: Reidy, Kimberly J., Hjorten, Rebecca C., Simpson, Claire L., Rosenberg, Avi Z., Rosenblum, Stacy D., Kovesdy, Csaba P., Tylavsky, Frances A., Myrie, Joseph, Ruiz, Bianca L., Haque, Soulin, Mozhui, Khyobeni, Nelson, George W., David, Victor A., Yang, Xiaoping, Suzuki, Masako, Jacob, Jack, Reznik, Sandra E., Kaskel, Frederick J., Kopp, Jeffrey B., Winkler, Cheryl A., Davis, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128247/
https://www.ncbi.nlm.nih.gov/pubmed/30173819
http://dx.doi.org/10.1016/j.ajhg.2018.08.002

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