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Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma

Despite the rapid growing and aging of populations worldwide, our knowledge on hepatocellular carcinoma (HCC) is still age-standardized rather than age-specific, with only few studies exploring the topic from a genetic point of view. Here, we analyze clinical and genetic aspects of HCC in patients o...

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Autores principales: Atyah, Manar, Yin, Yi-Rui, Zhou, Chen-Hao, Zhou, Qiang, Chen, Wan-Yong, Dong, Qiong-Zhu, Ren, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128442/
https://www.ncbi.nlm.nih.gov/pubmed/30125264
http://dx.doi.org/10.18632/aging.101531
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author Atyah, Manar
Yin, Yi-Rui
Zhou, Chen-Hao
Zhou, Qiang
Chen, Wan-Yong
Dong, Qiong-Zhu
Ren, Ning
author_facet Atyah, Manar
Yin, Yi-Rui
Zhou, Chen-Hao
Zhou, Qiang
Chen, Wan-Yong
Dong, Qiong-Zhu
Ren, Ning
author_sort Atyah, Manar
collection PubMed
description Despite the rapid growing and aging of populations worldwide, our knowledge on hepatocellular carcinoma (HCC) is still age-standardized rather than age-specific, with only few studies exploring the topic from a genetic point of view. Here, we analyze clinical and genetic aspects of HCC in patients of different age groups with the major attention directed to children (≤20 y) and elderly groups (≥80 y). A number of significant differences were found in elderly patients compared to children group, including smaller tumor size (P=0.001) and improved survival rates (P=0.002). Differences in gene mutations, copy number variants, and mRNA expressions were identified between the groups, with alteration rates for some genes like AKR1B10 increasing significantly with the age of patients. Immunohistochemistry testing of AKR1B10 showed a significant difference in expression levels at the age of 40 (30.77% high expression rate in patients younger than 40 compared to 51.57% in older patients) (P=0.043). Expression levels also differed between HCC tissues (49.64%) and near-tumor tissues (6.58%) (P<0.001). These findings contribute to the limited data available regarding the age-specific aspects of HCC patients, and support the need to address potential differences in the diagnosis, treatment, and prevention strategies of HCC.
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spelling pubmed-61284422018-09-10 Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma Atyah, Manar Yin, Yi-Rui Zhou, Chen-Hao Zhou, Qiang Chen, Wan-Yong Dong, Qiong-Zhu Ren, Ning Aging (Albany NY) Research Paper Despite the rapid growing and aging of populations worldwide, our knowledge on hepatocellular carcinoma (HCC) is still age-standardized rather than age-specific, with only few studies exploring the topic from a genetic point of view. Here, we analyze clinical and genetic aspects of HCC in patients of different age groups with the major attention directed to children (≤20 y) and elderly groups (≥80 y). A number of significant differences were found in elderly patients compared to children group, including smaller tumor size (P=0.001) and improved survival rates (P=0.002). Differences in gene mutations, copy number variants, and mRNA expressions were identified between the groups, with alteration rates for some genes like AKR1B10 increasing significantly with the age of patients. Immunohistochemistry testing of AKR1B10 showed a significant difference in expression levels at the age of 40 (30.77% high expression rate in patients younger than 40 compared to 51.57% in older patients) (P=0.043). Expression levels also differed between HCC tissues (49.64%) and near-tumor tissues (6.58%) (P<0.001). These findings contribute to the limited data available regarding the age-specific aspects of HCC patients, and support the need to address potential differences in the diagnosis, treatment, and prevention strategies of HCC. Impact Journals 2018-08-20 /pmc/articles/PMC6128442/ /pubmed/30125264 http://dx.doi.org/10.18632/aging.101531 Text en Copyright © 2018 Atyah et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Atyah, Manar
Yin, Yi-Rui
Zhou, Chen-Hao
Zhou, Qiang
Chen, Wan-Yong
Dong, Qiong-Zhu
Ren, Ning
Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma
title Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma
title_full Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma
title_fullStr Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma
title_full_unstemmed Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma
title_short Integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma
title_sort integrated analysis of the impact of age on genetic and clinical aspects of hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128442/
https://www.ncbi.nlm.nih.gov/pubmed/30125264
http://dx.doi.org/10.18632/aging.101531
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