In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs

The objective of this study was to investigate a possible mechanism of action of metronomic chlorambucil on glioma by studying the in vitro cytotoxicity and anti-angiogenic effects on glioma and endothelial cells, respectively. The in vitro LD(50) and IC(50) of chlorambucil were determined using hum...

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Detalles Bibliográficos
Autores principales: Reese, Michael J., Knapp, Deborah W., Anderson, Kimberly M., Mund, Julie A., Case, Jamie, Jones, David R., Packer, Rebecca A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128565/
https://www.ncbi.nlm.nih.gov/pubmed/30192852
http://dx.doi.org/10.1371/journal.pone.0203517

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