The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs

Purine nucleoside phosphorylases (PNPs) play an important role in the blood fluke parasite Schistosoma mansoni as a key enzyme of the purine salvage pathway. Here we present the structural and kinetic characterization of a new PNP isoform from S. mansoni, SmPNP2. Thermofluorescence screening of diff...

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Detalles Bibliográficos
Autores principales: Torini, Juliana Roberta, Romanello, Larissa, Batista, Fernanda Aparecida Heleno, Serrão, Vitor Hugo Balasco, Faheem, Muhammad, Zeraik, Ana Eliza, Bird, Louise, Nettleship, Joanne, Reddivari, Yamini, Owens, Ray, DeMarco, Ricardo, Borges, Júlio César, Brandão-Neto, José, Pereira, Humberto D’Muniz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128611/
https://www.ncbi.nlm.nih.gov/pubmed/30192840
http://dx.doi.org/10.1371/journal.pone.0203532

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