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Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

The ability to restrict low molecular weight compounds to the gastrointestinal (GI) tract may enable an enhanced therapeutic index for molecular targets known to be associated with systemic toxicity. Using a triazolopyrazine CSF1R inhibitor scaffold, a broad range of prodrugs were synthesized and ev...

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Detalles Bibliográficos
Autores principales:	George, Dawn M., Huntley, Raymond J., Cusack, Kevin, Duignan, David B., Hoemann, Michael, Loud, Jacqueline, Mario, Regina, Melim, Terry, Mullen, Kelly, Somal, Gagandeep, Wang, Lu, Edmunds, Jeremy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128612/ https://www.ncbi.nlm.nih.gov/pubmed/30192846 http://dx.doi.org/10.1371/journal.pone.0203567

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