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Role of simple descriptors and applicability domain in predicting change in protein thermostability

The melting temperature (Tm) of a protein is the temperature at which half of the protein population is in a folded state. Therefore, Tm is a measure of the thermostability of a protein. Increasing the Tm of a protein is a critical goal in biotechnology and biomedicine. However, predicting the chang...

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Detalles Bibliográficos
Autores principales: McGuinness, Kenneth N., Pan, Weilan, Sheridan, Robert P., Murphy, Grant, Crespo, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128648/
https://www.ncbi.nlm.nih.gov/pubmed/30192891
http://dx.doi.org/10.1371/journal.pone.0203819