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Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway

Transcription by RNA polymerase III (Pol III) is an essential cellular process, and mutations in Pol III can cause neurodegenerative disease in humans. However, in contrast to Pol II transcription, which has been extensively studied, the knowledge of how Pol III is regulated is very limited. We repo...

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Detalles Bibliográficos
Autores principales: Wang, Zheng, Wu, Catherine, Aslanian, Aaron, Yates, John R, Hunter, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128692/
https://www.ncbi.nlm.nih.gov/pubmed/30192228
http://dx.doi.org/10.7554/eLife.35447